Purification of Recombinant Fusion Polypeptide hEGF-AWRK6 and Effect on Wound Healing and Infection of Burn Model Mice

    October 2018 in “ PubMed ”
    Chunlin Zhao, Lili Jin, Sijia Tai, Xuemin Zhang, Tiancong Shi, Fei Wu, Qiuyu Wang
    TLDR EK significantly improved wound healing and reduced infection in burn wounds.
    The study tested the therapeutic effect of the recombinant fusion polypeptide hEGF-AWRK6 (EK) on burn infections in model mice. EK was expressed and purified using an Escherichia coli system, and its effects were compared to PBS, gentamicin, and burn ointment. Results showed that EK had significant antibacterial activity against Pseudomonas aeruginosa, with a notable decrease in colony count and an increase in wound healing rate (P<0.01). Pathological analysis revealed that EK-treated wounds had more regular dermal cell arrangement, increased hair growth, and faster epithelization. These findings suggested that EK could be a promising candidate for developing treatments for burn wounds.
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