Purification of Recombinant Fusion Polypeptide hEGF-AWRK6 and Effect on Wound Healing and Infection of Burn Model Mice

    October 2018 in “ PubMed ”
    Chunlin Zhao, Lili Jin, Sijia Tai, Xuemin Zhang, Tiancong Shi, Fei Wu, Qiuyu Wang
    TLDR EK significantly improved wound healing and reduced infection in burn wounds.
    The study investigated the therapeutic effects of the recombinant fusion polypeptide hEGF-AWRK6 (EK) on burn infections in a mouse model. EK was expressed and purified using an Escherichia coli system. Mice with Ⅱ degree burns and Pseudomonas aeruginosa infections were treated with EK (30 mg/L), while control groups received PBS, gentamicin, or burn ointment. Results showed that EK significantly reduced bacterial colony counts and increased wound healing rates compared to controls (P<0.01). Pathological analysis revealed that EK-treated wounds had more organized dermal cells, increased hair growth, and faster epithelization. These findings suggested that EK could be a promising candidate for developing treatments for burn wounds.
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