Epidermal Growth Factor in Aesthetics and Regenerative Medicine: Systematic Review

January 2021 in “ Journal of Cutaneous and Aesthetic Surgery ”

DubraskaV Suárez-Vega, Blanca Miller-Kobisher, GladysJ Velazco de Maldonado

recombinant human Epidermal Growth Factor rhEGF Epidermal Growth Factor EGF skin regeneration hair recovery intradermal application topical application skin aging hyperpigmentation acne stretch marks

TLDR Epidermal growth factor helps skin and hair regeneration but needs more research for better understanding.

The systematic review examined the use of recombinant human Epidermal Growth Factor (rhEGF) in aesthetics and regenerative medicine, analyzing 49 articles with 821 patients. It found rhEGF effective in promoting skin regeneration, restructuring, and hair recovery, particularly through intradermal and topical applications. EGF improved signs of skin aging, such as wrinkles and hydration, and was effective in treating hyperpigmentation, acne, and stretch marks. Despite its potential, the evidence was not robust due to uncontrolled or non-randomized trials, and transient adverse effects were noted. The review emphasized the need for more controlled studies to establish optimal therapeutic protocols and fully understand EGF's capabilities in clinical settings.