Biophysical and Metabolic Cues in the Microenvironment of Skin Wounds: Implications for Stem Cell Behavior and Epidermal Regeneration

The document emphasizes the critical role of biophysical and metabolic cues in the microenvironment of skin wounds, which significantly affect stem cell behavior and epidermal regeneration. Unlike traditional reviews that focus on soluble mediators, this paper highlights recent evidence showing that factors such as oxygen tension, nutrient availability, tissue mechanics, surface pH, ionic composition, and endogenous electric fields play a crucial role in influencing the activity of epidermal and hair follicle stem cells, dermal progenitors, and transplanted stem cells during wound healing. Understanding these factors is vital for developing advanced treatments for burns and other skin injuries.