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Effective PCOS treatments require targeting specific signaling pathways.

A specific gene variant is linked to a higher risk of hair loss from chemotherapy in breast cancer patients.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Androgenetic alopecia in men is genetic and linked to health issues like obesity and heart disease, with treatments including minoxidil, finasteride, and hair transplants.

Sex hormones like estrogen and testosterone may affect COVID-19 severity differently in men and women, potentially influencing prevention and treatment strategies.

Some lesser-known causes of PCOS include autoimmune issues, genetic mutations, and changes in the body's microbiome.

The research identified key proteins that affect wool fiber thickness in Angora rabbits.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.

New treatments for hair loss are showing promise due to better understanding of genetics and the immune system.

Polycystic ovary syndrome is a common hormonal disorder in women, linked to increased risk of metabolic and heart diseases, and needs more research for better understanding and treatment.

Right hand finger ratio may predict male hair loss.

COVID-19 may worsen with androgens; anti-androgen drugs could help.

The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.

Melatonin directly affects mouse hair follicles and may influence hair growth.

The Rotterdam Study investigates diseases in older adults and has produced many research findings.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The Rotterdam Study aims to understand various diseases in older adults.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

Androgens may block hair growth signals, targeting this could treat hair loss.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

Behçet's Disease may be caused by genetic and environmental factors leading to abnormal immune responses, and stress management and new treatments could improve patient outcomes.

Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.

Alopecia areata, a type of hair loss, is likely an autoimmune disease with a genetic link, but its exact cause is still unknown.