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    Glossary Epidermal Hyperproliferation

    rapid and excessive growth of skin's outermost layer

    Epidermal hyperproliferation refers to the rapid and excessive growth of the outermost layer of the skin, known as the epidermis. This condition is often seen in skin disorders like psoriasis, where skin cells multiply much faster than normal, leading to thickened, scaly patches.

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    1. Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation Molecular and cellular biology · 2002 · 108 citations
    2. Connexin 30, a new marker of hyperproliferative epidermis British Journal of Dermatology · 2006 · 18 citations
    3. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009 · 503 citations
    4. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling Development · 2011 · 134 citations
    5. Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis Cell death and differentiation · 2011 · 76 citations
    6. Type XVII collagen suppresses interfollicular epidermal proliferation in neonatal and aged skin, and helps rejuvenate epidermis 2017
    7. Faculty Opinions recommendation of Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    8. A 5'-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice. Proceedings of the National Academy of Sciences · 1995 · 46 citations
    9. Analysis of Sequences Controlling Tissue-Specific and Hyperproliferation-Related Keratin 6 Gene Expression in Transgenic Mice DNA and Cell Biology · 1998 · 26 citations
    10. The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function 2013 · 1 citations
    11. The dark and the bright sides of the transcription factor Nrf2 in skin protection and disease (Nrf2 and epidermal barrier function) Free Radical Biology and Medicine · 2015
    12. Conditional epidermal expression of TGFβ1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia Proceedings of the National Academy of Sciences · 2001 · 103 citations
    13. Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis The EMBO Journal · 2013 · 65 citations
    14. Neuregulin3 alters cell fate in the epidermis and mammary gland BMC developmental biology · 2007 · 39 citations
    15. Conditional Knockout in Mice Reveals the Critical Roles of Ppp2ca in Epidermis Development International Journal of Molecular Sciences · 2016 · 14 citations
    16. Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis International journal of molecular sciences · 2024 · 1 citations
    17. Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. The EMBO Journal · 1995 · 252 citations
    18. High proliferation and delamination during skin epidermal stratification Nature Communications · 2021 · 51 citations
    19. Keratinocyte-derived follistatin regulates epidermal homeostasis and wound repair Laboratory investigation · 2008 · 28 citations
    20. A two-phase model of skin epidermal stratification: lessons from centrosomes bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 1 citations
    21. The RATIOnal Role of Polyamines in Epidermal Differentiation Journal of Investigative Dermatology · 2021
    22. 707 Chromatin remodeler Lymphoid-specific helicase (Lsh) is a critical determinant controlling postnatal epidermal growth, differentiation and response to injury Journal of Investigative Dermatology · 2016
    23. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations 2011 · 41 citations
    24. Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro Differentiation · 1987 · 135 citations
    25. Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia Developmental biology · 1999 · 69 citations
    26. Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes Experimental Dermatology · 2000 · 58 citations
    27. Disturbed Epidermal Structure in Mice with Temporally Controlled Fatp4 Deficiency 2005 · 39 citations
    28. Inducible deletion of epidermal <i>Dicer</i> and <i>Drosha</i> reveals multiple functions for miRNAs in postnatal skin Development · 2012 · 82 citations
    29. Author response: Type XVII collagen coordinates proliferation in the interfollicular epidermis 2017
    30. Decision letter: Type XVII collagen coordinates proliferation in the interfollicular epidermis 2017