January 2023 in “Postępy Dermatologii i Alergologii” This review provides an overview of azelaic acid's dermatological uses, mechanisms, and its potential in skin cancer treatment, but reports no new clinical results.
September 2025 in “Journal of Applied Biological Chemistry” In a laboratory study, Grateloupia elata extract demonstrated antioxidant and anti-aging effects by scavenging free radicals, inhibiting collagenase and elastase, increasing procollagen production, and reducing MMP-1 secretion, suggesting its potential use in functional cosmetics.
February 2025 in “Universidade Nova de Lisboa's Repository (Universidade Nova de Lisboa)” This research discusses various collaborative and funding efforts across multiple institutions but does not present new experimental findings.
July 2025 in “Carbohydrate Polymers” This study investigated the extracellular polysaccharides from the edible green alga Parachlorella sp. BX1.5, finding that they have potential applications in cosmetics and health products due to their stability, antioxidant properties, and effects on hair growth in mice.
August 2024 in “Skin Research and Technology” This study found that omega-6 and certain LDL cholesterol fractions are risk factors for androgenetic alopecia, suggesting a causal link between these lipid-related metabolites and the condition, which could inform future therapeutic approaches.
May 2024 in “Journal of cosmetic dermatology” This study investigated the effects of heat-treated Limosilactobacillus fermentum LM1020 on hair growth and reported increased hair density, improved cellular activity, and beneficial scalp microbiota changes in patients with androgenetic alopecia over 24 weeks.
November 2023 in “International Journal of Pharmaceutics” This study reported that a novel ionic liquid delivery system combining ferulic acid and finasteride enhanced the solubility, skin permeation, and effectiveness in promoting hair regrowth in androgenetic alopecia mice, suggesting an improved topical treatment approach.
February 2026 in “Nano Research” This study developed a dissolvable microneedle system delivering specific molecules to remodel lymphatic networks and normalize metabolic processes, which accelerated hair growth and activated hair follicle stem cells in a mouse model of androgenetic alopecia.
20 citations
,
May 1985 in “British journal of nutrition” This study found that in genetically diabetic mice, supplementation with safflower or evening primrose oil prevented the decrease in certain fatty acids and improved skin conditions, but increased plasma glucose levels.
12 citations
,
July 2017 in “International Journal of Cosmetic Science” This study found that N‐AOHPA was particularly effective as a silicone emulsifier for improving the condition of damaged hair by preventing amino acid dissolution from bleached hair.
January 2026 in “Biomacromolecules” This study reports that a novel nanolipogel with moderate rigidity (NLG-2.5) enhances transdermal delivery of fucosterol, displaying superior permeability, targeting hair follicles, and promoting hair growth in androgenetic alopecia model mice by inhibiting inflammation and androgen pathways and promoting angiogenesis.
2 citations
,
May 2025 in “Frontiers in Immunology” This study explores the regulatory effects of ursolic acid on macrophage function and suggests potential for developing new anti-inflammatory and immunomodulatory drugs, though further research is needed for clinical applications.
2 citations
,
April 2025 in “Plants” This study found that lambertianic acid from Platycladus orientalis leaves may protect against dexamethasone-induced skeletal muscle atrophy by reducing atrophy-related proteins without affecting cell viability.
March 2025 in “Journal of Investigative Dermatology”
May 2024 in “Chemical engineering journal” This study reports that a new minoxidil and epigallocatechin gallate co-loaded ionic liquids system showed superior efficacy in promoting hair regrowth in a mouse model of androgenic alopecia by activating hair follicle stem cells and improving microenvironment conditions, compared to existing minoxidil products.
11 citations
,
September 2010 in “PubMed” In this study, the researchers compared the pharmacokinetics and tissue distribution of dihydroartemisinin in nanostructured lipid carriers versus in solution, finding longer mean residence times and variable organ accumulation with the nanostructured lipid carriers.
September 2021 in “Han'gug mi'saengmul saengmyeong gong haghoeji/Han-guk misaengmul saengmyeong gonghak hoeji” This study found that an ethanolic extract from the microalga Tetrathelmis tetrathele exhibited anti-inflammatory effects, promoted the proliferation of certain skin and hair cells, and inhibited 5α-reductase activity, suggesting its potential as a therapeutic agent for preventing alopecia and enhancing scalp health.
May 2025 in “Journal of Nanobiotechnology” This study reported that an ATRA-loaded nanostructured lipid carrier gel (ATRA-NLC-Gel) improved symptoms of alopecia areata in mice by enhancing transdermal drug delivery, reducing skin irritation, and promoting hair regrowth through targeted follicle enrichment and pathway activation.
April 2026 in “Applied Sciences” This review summarizes current knowledge on succinic acid's applications in cosmetics and aesthetic dermatology, highlighting its potential benefits such as inflammation modulation and collagen production, although most supporting studies are small or preliminary, indicating a need for further research to validate these uses.
109 citations
,
April 1997 in “Journal of Lipid Research” This study found that pure linoleate deficiency in rats caused significant reductions in the accumulation of n-6 polyunsaturates and mild symptoms like growth retardation, compared to classical essential fatty acid deficiency.
June 2023 in “Skin Research and Technology” The researchers reported that an oral supplement containing hydrolysed fish-origin collagen, taurine, cysteine, methionine, iron, and selenium significantly improved the effectiveness of anti-hair loss treatments in people with androgenic alopecia or chronic telogen effluvium after 12 weeks, compared to drug treatments alone.
December 2025 in “Medicine” This study suggests potential causal links between blood levels of glutamine, citric acid, glucose, various lipids, and lipoproteins with alopecia areata, finding glutamine may have a protective effect and noting no evidence of reverse causality. Further research is needed to validate these associations.
6 citations
,
October 2016 in “Pediatric Dermatology” This case report describes a unique instance of a 6-year-old girl developing angioedema after treatment with squaric acid dibutylester for alopecia areata.
September 2025 in “JID Innovations” This study suggests that macrophages, particularly CD206+ macrophages, play a crucial role in squaric acid dibutylester-induced hair growth in alopecia areata treatment.
March 2026 in “Inflammopharmacology” This study found that ursolic acid at 50 mg/kg improved biochemical, hormonal, and ovarian histopathological markers in a rat model of PCOS, suggesting its potential as a therapeutic option.
January 2026 in “Journal of Ethnopharmacology” Cedrol promotes hair growth better than baricitinib by regulating immune cells.
27 citations
,
January 2005 in “American Journal of Clinical Dermatology” This pilot study found that azelaic acid treatment for patchy alopecia areata had similar hair regrowth results as anthralin, suggesting it may be an effective topical therapy.
2 citations
,
March 2025 in “Journal of Translational Autoimmunity” This study reports that AhR pathway expression is significantly reduced in lymphocytes of alopecia areata patients, suggesting its potential as a diagnostic marker and therapeutic target.
May 2023 in “Scientific Reports” This study found that Lepidium sativum seed extract showed potential in treating alopecia in rats by reducing 5(alpha)-dihydrotestosterone levels and improving hair length compared to minoxidil.
1 citations
,
January 2025 in “RSC Advances” The researchers evaluated scientific data on the usage and pharmaceutical applications of ascorbic acid derivatives, such as ascorbyl-6-palmitate and ascorbyl-2-glucoside, highlighting their development into stable delivery platforms to overcome ascorbic acid's instability and formulation challenges.