Causal Effects of Omega-6 and LDL-C on Androgenetic Alopecia: A Mendelian Randomization Study

August 2024 in “ Skin Research and Technology ”

Liu Peilong, Quanlin Zhao, Shuqing Gong

omega-6 LDL-C androgenetic alopecia lipid-related metabolites total cholesterol medium LDL small LDL SNPs AGA LDL

TLDR Omega-6 and LDL cholesterol increase the risk of hair loss.

This Mendelian randomization study involving 136,016 participants found that higher levels of Omega-6 fatty acids and total cholesterol in LDL, medium LDL, and small LDL are significant risk factors for androgenetic alopecia (AGA), with odds ratios ranging from 1.54 to 1.62. Other lipid-related metabolites, such as serum HDL-C, total cholesterol in large LDL, and Omega-3 fatty acids, did not show reliable causal relationships with AGA. The bidirectional approach confirmed that AGA does not significantly affect the selected lipid-related metabolites, ensuring the robustness of the findings.

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research Causal Effects of Lipids-Related Metabolites on Androgenic Alopecia: A Mendelian Randomization Study

February 2024 in “Clinical, Cosmetic and Investigational Dermatology”

Certain fats in the blood are linked to an increased risk of male pattern baldness.

Efficacy and Tolerability of an Oral Supplement Containing Amino Acids, Iron, Selenium, and Marine Hydrolyzed Collagen in Subjects With Hair Loss: A Prospective, Randomized, 3-Month, Controlled, Assessor-Blinded Study

research Efficacy and Tolerability of an Oral Supplement Containing Amino Acids, Iron, Selenium, and Marine Hydrolyzed Collagen in Subjects With Hair Loss: A Prospective, Randomized, 3-Month, Controlled, Assessor-Blinded Study

June 2023 in “Skin Research and Technology”

The supplement with amino acids, iron, selenium, and marine hydrolyzed collagen improved hair growth more than drug treatment alone, with most people tolerating it well.

research Rare and Common Genetic Determinants of Metabolic Individuality and Their Effects on Human Health

29 citations, November 2022 in “Nature Medicine”

Genetic variations greatly affect individual metabolism and can impact health and disease risk.

research Androgenetic Alopecia

January 2022 in “DOAJ (DOAJ: Directory of Open Access Journals)”

An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects

research An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects

2 citations, August 2020 in “Cosmetics”

Herbal formula shows promise for hair loss treatment.

research Genetic and Molecular Aspects of Androgenetic Alopecia

24 citations, May 2018 in “Indian Journal of Dermatology, Venereology and Leprology”

research Androgenetic Alopecia

1 citations, January 2018 in “Jaypee Brothers Medical Publishers (P) Ltd. eBooks”

research Hair Loss: Common Causes and Treatment

35 citations, September 2017 in “PubMed”

The document concludes that hair loss has many causes and treatments vary, including medication for pattern baldness and addressing underlying issues for other types.

research Androgenetic Alopecia: A Review

153 citations, March 2017 in “Endocrine”

Male pattern baldness involves genetics, hormones, and needs better treatments.

research Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial

36 citations, January 2014 in “Evidence-based Complementary and Alternative Medicine”

Pumpkin seed oil helps hair growth in men with hair loss.

research Androgenetic Alopecia

May 2013 in “Springer eBooks”

research Alopecia: Evaluation and Treatment

76 citations, July 2011 in “Clinical, Cosmetic and Investigational Dermatology”

The document concludes that proper diagnosis and FDA-approved treatments for different types of hair loss exist, but treatments for severe cases often fail and future improvements may focus on hair follicle stem cells.