Squaric Acid Dibutylester Promotes Innate Immune-Driven Hair Growth with CD206+ Macrophage Accumulation in the Dermis

    September 2025 in “ JID Innovations ”
    Koichi Tomii, Madoka Ozawa, Yasuhiro Kanda … Tomoya Katakai
    Studysummary This study suggests that macrophages, particularly CD206<sup>+</sup> macrophages, play a crucial role in squaric acid dibutylester-induced hair growth in alopecia areata treatment.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jidinnovations.org →
    Discuss this study in the Community →

    Research cited in this study 15

    1. Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence Nature · 2021
    2. Dermal Macrophage and Its Potential in Inducing Hair Follicle Regeneration Molecular Immunology · 2021
    3. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    4. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    5. Frontiers in Alopecia Areata Pathobiology Research ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2019
    6. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
    7. M2 Macrophages Promote Wound-Induced Hair Neogenesis Journal of Dermatological Science · 2018
    8. Alopecia Areata: Animal Models Illuminate Autoimmune Pathogenesis and Novel Immunotherapeutic Strategies Autoimmunity reviews · 2016
    9. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    10. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    11. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    12. Delayed type hypersensitivity‐induced myeloid‐derived suppressor cells regulate autoreactive T cells European Journal of Immunology · 2011
    13. Restoration of Hair Growth in Mice with an Alopecia Areata-Like Disease Using Topical Anthralin Experimental Dermatology · 2004
    14. Efficacy of Topical Sensitizers in the Treatment of Alopecia Areata Journal of the American Academy of Dermatology · 1998
    15. Alopecia Areata in Aging C3H/HeJ Mice Journal of Investigative Dermatology · 1994