This study found that in the Indian population, SLE patients with only skin manifestations often had a positive immunological profile, suggesting early identification of disease before systemic symptoms develop.
This study found that all examined biomarkers and clinical features were elevated in systemic lupus erythematosus patients, particularly ANA and Anti-dsDNA autoantibodies, but no single biomarker was sensitive or specific enough for diagnosis.
August 2021 in “BMJ Case Reports” This case report details a 27-year-old woman's diagnosis of systemic lupus erythematosus with immune-mediated intravascular haemolysis, which improved with steroid treatment.
February 2021 in “Indonesian Journal of Perinatology” This study found that among 26 pregnant patients with Systemic Lupus Erythematosus, the most common pregnancy complication was intrauterine growth restriction.
January 2020 in “SSRN Electronic Journal” This study observed distinct clusters of autoantibodies in children with pSLE, with significant differences in several clinical manifestations like hair loss, oral ulcers, arthritis, neurological symptoms, renal issues, and AIHA among the clusters.
February 2018 in “Chin J Clinicians(Electronic Edition)” This study found that rash in SLE patients is prevalent and associated with more severe disease indicators, including certain clinical manifestations and serological abnormalities.
This study found that the age of onset in systemic lupus erythematosus patients affects clinical features, with juvenile-onset SLE showing more severe disease activity and systemic involvement than adult or late-onset SLE.
January 2014 in “Journal of Jilin University” This study found that Th22 cells and their cytokine IL-22 may play an important role in the pathogenesis of systemic lupus erythematosus and could serve as bioindicators for monitoring disease severity.
64 citations
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May 2000 in “International Journal of Dermatology” This study found that thalidomide increased peripheral lymphocyte counts and reduced inflammation in lupus erythematosus patients, but was associated with polyneuropathy, suggesting careful use in refractory cases.
May 2021 in “Journal of Advances in Internal Medicine” This case report describes a 13-year-old with DSD raised as female, exhibiting hoarseness and clitoral enlargement, with hormonal assessments not indicating common related deficiencies.
31 citations
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March 2018 in “Frontiers in Immunology” This article reviews the complexities and challenges in classifying systemic lupus erythematosus and the problematic role of the anti-dsDNA antibody as a biomarker, without presenting new experimental findings.
2 citations
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September 2024 in “Asian Journal of Andrology” In a retrospective cohort of patients with steroid 5 α-reductase 2 deficiency, this study identified seven novel genetic variants in the SRD5A2 gene, expanding the variant database and contributing to improved diagnostic and therapeutic approaches for the condition.
70 citations
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April 2014 in “Annales d'endocrinologie” This review discusses the pathways of androgen biosynthesis and reports no new findings, highlighting the need to understand the interplay between the classic and backdoor pathways.
January 2025 in “Case Reports in Genetics” The researchers identified a pathogenic variant in the SRD5A2 gene among siblings with 46,XY disorder of sexual development, highlighting the importance of comprehensive genetic testing in diagnosis and management.
June 2026 in “The Journal of Sexual Medicine” This case report describes an extremely rare instance of seminoma in an adult with SRY-negative 46,XX testicular disorder of sex development, uniquely presenting as acute abdomen due to gonadal torsion.
October 2023 in “Journal of Integrative Medicine and Research” This case report describes a patient with lupus nephritis coexisting with discoid lupus erythematosus and vitiligo, noting improvement in proteinuria and DLE lesions following treatment, while vitiligo lesions persisted.
9 citations
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October 2017 in “Translational pediatrics” This review examines the skin manifestations of various endocrine disorders, highlighting their underlying pathophysiology and impact on an individual's health and quality of life, without reporting new research findings.
4 citations
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July 2017 in “Journal of Medical Case Reports” This case report highlights a rare presentation of acute lupus hemophagocytic syndrome with initially negative antinuclear antibodies, underscoring the higher sensitivity of the 2012 Systemic Lupus International Collaborating Clinics criteria for diagnosis.
1 citations
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February 2022 in “Online journal of biological sciences” This article reviews the congenital disorder aphallia, describing its rarity, clinical characteristics, and the normal hormonal and chromosomal profiles of affected individuals, but does not report new research findings.
1 citations
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September 2019 in “Steroids” In this study, genetic testing confirmed the diagnosis of Androgen insensitivity syndrome in most CAIS patients in Tunisia and identified two previously unreported mutations in the androgen receptor gene.
August 2025 in “American Journal of Case Reports” In this case report, researchers describe a 13-year-old phenotypic female with 46,XY karyotype, previously misdiagnosed with androgen insensitivity syndrome, who was later identified to have 17-beta-hydroxysteroid dehydrogenase type 3 deficiency, underscoring the importance of genetic and hormonal tests for accurate diagnosis of sex development disorders.
This study found that the novel bacteriophage Halo KS-7 shows strong antibacterial activity against carbapenem-resistant Klebsiella pneumoniae and significantly promotes wound healing in mice, making it a promising biocontrol agent for managing multidrug-resistant infections.
May 2025 in “The Journal of Rheumatology” This case report describes a woman whose initial presentation of SLE was persistent watery diarrhea, diagnosed as lymphocytic enterocolitis, and shows that immunosuppressive therapy resulted in symptom relief.
April 2025 in “Dermatología Argentina” This study found that simultaneous presence of specific and nonspecific skin lesions, or having three or more types of skin lesions, was associated with increased systemic activity of systemic lupus erythematosus.
May 2018 in “The Journal of Immunology” In this study, daily treatment with angiotensin (1-7) significantly reduced disease severity in a mouse model of Systemic Lupus Erythematosus, suggesting potential for Mas agonists in future therapies.
November 2017 in “Journal of Surgical Academia” This case report describes a woman with systemic lupus erythematosus who developed non-progressive visual field defects after hypertensive retinopathy, with cotton wool spots indicating retinal nerve fiber microinfarctions.
January 2008 in “Di-san junyi daxue xuebao” This study found that hair follicle stem cells from young rats can be induced in vitro to differentiate into corneal epithelium-like cells using homogenate of rabbit corneal limbal stroma.
January 2005 in “Di-san junyi daxue xuebao” This study found that VEGF significantly promoted hair follicle growth and regeneration in mice with scleroderma.
January 2005 in “Di-san junyi daxue xuebao” This study found that treatment with aerosol bioelectricity accelerated wound healing in burned rats by enhancing the expression of EGF and β_1 integrin in skin basal and hair follicle cells.
January 2001 in “Acta Academiae Medicine Militaris Tertiae” In this study, the researchers reported that the expression of keratin 14 in the skin and hair follicles of neonatal and juvenile rats differs from that observed in adults or human embryos.