Clinical Analysis of Rash in Systemic Lupus Erythematosus

    February 2018 in “ Chin J Clinicians(Electronic Edition) ”
    Wengen Li, Xuechun He
    TLDR Rash in SLE patients indicates more severe disease.
    The study analyzed 661 patients with systemic lupus erythematosus (SLE) from 2010 to 2016, focusing on the clinical significance of rashes. It found that 338 patients (51.1%) had rashes, which were associated with higher incidences of fever, oral ulcers, hair loss, and arthritis compared to those without rashes. Patients with rashes had lower serum C3 levels and higher positivity rates for anti-dsDNA and anti-Sm antibodies. Logistic regression identified oral ulcers, hair loss, and arthritis as risk factors for rashes, while older age at onset, absence of anemia, and normal C3 levels were protective factors. The presence of rashes in SLE patients indicated a higher likelihood of multi-system involvement.
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