Influence of Aerosol Bioelectricity on Expression of Epidermal Growth Factor and β1 Integrin in Healing Wounds of Burned Rats

The study investigated the effects of aerosol bioelectricity on wound healing in burned Sprague Dawley rats, focusing on the expressions of epidermal growth factor (EGF) and β_1 integrin. The experimental group (n=20) treated with aerosol bioelectricity showed faster wound healing (7±1.15 days) compared to the control group (n=20) (9±1.34 days). EGF and β_1 integrin expressions were detected earlier and at higher levels in the experimental group, particularly in skin basal and hair follicle cells, indicating enhanced cell proliferation. The findings suggested that aerosol bioelectricity could accelerate wound healing by up-regulating EGF and β_1 integrin expressions.