Comparison of Clinical Characteristics Among Different Times of Disease Onset in Patients with Systemic Lupus Erythematosus

The study analyzed 453 SLE patients from Meizhou People's Hospital, dividing them into juvenile-onset (JSLE), adult-onset (ASLE), and late-onset (LSLE) groups. Fever, rash, arthritis, renal involvement, and anemia were common across all groups, with JSLE patients experiencing more frequent fever and higher disease activity. JSLE and ASLE patients had higher incidences of rash, hair loss, splenomegaly, lymphadenectasis, and renal involvement compared to LSLE patients. LSLE patients had lower anti-dsDNA but higher anti-SSA antibody prevalence. The findings indicated that JSLE patients had more severe systemic involvement and required more aggressive treatment.