January 2022 in “Indian Journal of Paediatric Dermatology” This case study reports that patchy nonscarring alopecia without systemic involvement can be an atypical initial indication of juvenile onset systemic lupus erythematosus.
This study found that the age of onset in systemic lupus erythematosus patients affects clinical features, with juvenile-onset SLE showing more severe disease activity and systemic involvement than adult or late-onset SLE.
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February 2025 in “Frontiers in Medicine” This study found that patients with juvenile-onset systemic lupus erythematosus have a high prevalence of endocrine and metabolic comorbidities, particularly dyslipidemia and obesity-related issues, suggesting the need for routine monitoring and obesity prevention.
May 2026 in “Indian Journal of Dermatology” This study reports that Rituximab may be a safe and effective treatment for refractory juvenile systemic lupus erythematosus complicated by macrophage activation syndrome, allowing for successful steroid tapering.
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January 2015 in “Pediatric Rheumatology” This review highlights the importance of recognizing mucocutaneous lesions in diagnosing juvenile-onset systemic lupus erythematosus, noting that these lesions often improve with controlled lupus and can indicate disease activity.