Autoantibodies in Pediatric SLE: Cluster Analysis and Clinical Associations, a Single Center Cohort Study

    January 2020 in “ SSRN Electronic Journal ”
    Siva Vyasam, Rahul Reddy, Visalakshi Jeyaseelan, John Jude Prakash, Sathish Kumar
    TLDR Different autoantibody groups in pediatric SLE are linked to specific symptoms and disease outcomes.
    The study on pediatric SLE (pSLE) identified distinct clusters of autoantibodies associated with specific clinical manifestations. Involving 212 newly diagnosed pSLE patients, cluster analysis revealed three main groups: Cluster 1 with anti-dsDNA and ANA antibodies, Cluster 2 with multiple autoantibodies including anti-dsDNA, ANA, anti-RNP, and anti-Sm, and Cluster 3 with anti-dsDNA, ANA, anti-cardiolipin, and anti-SSA antibodies. Significant differences among clusters were found for hair loss, oral ulcers, arthritis, neurological symptoms, renal manifestations, and AIHA. The findings emphasized the importance of comprehensive autoantibody profiling to predict disease course and major organ involvement in pSLE.
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