Childhood Systemic Lupus Erythematosus: Clinical and Immunologic Patterns in Mexican Children

    May 2024 in “ Cureus ”
    Edgar E Morales Montes, I. Herrera, Yesenia Hernández Torres, Laura Pérez, Luis Alberto Aparicio-Vera
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    Studysummary This study in childhood-onset systemic lupus erythematosus (cSLE) patients found significant gender differences, with males exhibiting more serositis, higher anti-DNA antibody prevalence, and renal involvement, while females experienced more hair loss.
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    This study analyzed 89 Mexican children with childhood-onset systemic lupus erythematosus (cSLE), including 23 males and 66 females, to compare clinical and immunologic patterns by gender. Males exhibited higher prevalence of serositis, positive anti-DNA antibodies (88.9% vs. 42.9%), and renal involvement, including granular casts, proteinuria, and lower glomerular filtration rates. Females showed more hair loss. Males had higher average hemoglobin levels (11.47 g/dL vs. 9.84 g/dL) and more frequent use of hydroxychloroquine, cyclophosphamide, and mycophenolate. The study suggests that gender-specific analysis could improve treatment strategies for cSLE.
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