Clinical Expression and Morbidity of Systemic Lupus Erythematosus During a Post-Diagnostic 5-Year Follow-Up: A Male to Female Comparison

June 2011 in “ Lupus ”

S Stefanidou, Alexis Benos, Vasiliki Galanopoulou, I Chatziyannis, F. Kanakoudi, Spyros Aslanidis, Konstantinos Tselios, T. Sfetsios, Loukas Settas, Marios Katsounaros, Dorothea Papadopoulou, Panagiotis Giamalis, Nicholas Dombros, M Chatzistilianou, Alexandros Garyfallos

hair loss photosensitivity Raynaud’s phenomenon arthralgia nephropathy myositis tendonitis

TLDR Gender affects the symptoms and severity of systemic lupus erythematosus.

The study compared the clinical expression and morbidity of systemic lupus erythematosus (SLE) between male and female patients over a 5-year follow-up period. It found that male patients with SLE had worse cardiovascular and renal outcomes compared to female patients. The research highlighted the importance of considering gender differences in the management and treatment of SLE, as males exhibited more severe disease manifestations and higher morbidity rates. The study emphasized the need for tailored therapeutic approaches to address these disparities effectively.

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research Clinical Manifestations of Cutaneous Lupus Erythematosus

148 citations, February 2005 in “Autoimmunity Reviews”

Most people with systemic lupus erythematosus have skin problems, and skin symptoms are often the first sign of the disease.