Immune-Mediated Coombs Negative Intravascular Hemolysis in Systemic Lupus Erythematosus
August 2021
in “
BMJ Case Reports
”
New to Prednisolone? There is a guide in the encyclopedia. Read the guide → Studysummary This case report details a 27-year-old woman's diagnosis of systemic lupus erythematosus with immune-mediated intravascular haemolysis, which improved with steroid treatment.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The document discussed a rare case of immune-mediated Coombs negative intravascular hemolysis in a 27-year-old woman with systemic lupus erythematosus (SLE). Despite presenting with symptoms of hemolysis, standard Coombs tests were negative. The patient exhibited excessive hair loss, weight loss, amenorrhea, fever, and abdominal pain, with lab results showing a drop in hemoglobin, indirect hyperbilirubinemia, raised LDH, and hemoglobinuria. Positive antinuclear and anti-dsDNA antibodies confirmed SLE. Treatment with prednisolone and hydroxychloroquine resolved the hemolysis, with no further episodes during follow-up. The case underscored the need for alternative diagnostic approaches and heightened clinical awareness in managing atypical SLE presentations.
