Detection of Subtypes of T Helper Cells and Their Cytokines in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Their Clinical Significances

    January 2014 in “ Journal of Jilin University ”
    Lin Zhao
    TLDR Higher levels of certain immune cells and proteins are linked to more severe lupus symptoms.
    The study investigated the changes and clinical significance of T helper cell subtypes (Th22, Th17, and Th1) and their cytokines in the peripheral blood of 30 patients with systemic lupus erythematosus (SLE) compared to 30 healthy controls. It found that the ratios of Th22, Th17, and IL-22+Th1 cells, as well as the levels of plasma IL-22 and IL-17, were significantly higher in SLE patients. There was a positive correlation between Th17 and Th22 cell ratios and between Th22 cell ratios and plasma IL-22 levels. Increased ratios of IL-22+CD4+T and IL-22-Th17 cells correlated with higher disease activity scores. Th22 cell ratios were higher in patients with facial erythema, hair loss, and positive anti-nuclear antibody (ANA), while Th17 cell ratios were higher in patients with light allergies or positive anti-dsDNA. The study concluded that IL-22+CD4+T cells, particularly Th22 cells and their cytokine IL-22, played a crucial role in SLE pathogenesis and could serve as biomarkers for disease severity.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Hair Loss Results After 8 Months of Dutasteride

      in Progress Pictures  232 upvotes 1 month ago
      The user experienced increased hair density after 8 months of using dutasteride and 6 months of oral minoxidil. Some users joked about side effects, while others discussed the effectiveness of various treatments like finasteride and rosemary oil.

      community Hair Loss Due To Chlorine and Hard Metals In Water?

      in Research/Science  1 upvotes 2 months ago
      Hair loss possibly caused by chlorine and heavy metals in water was addressed by using a shower filter, ketoconazole shampoo, and PRP sessions, which stopped the hair loss but did not lead to regrowth. Other users suggested similar experiences and solutions, emphasizing the importance of a good water filter and patience for potential regrowth.

      community Hair Loss Treatments and Hair Transplant

      in Progress Pictures  4 upvotes 2 months ago
      The user is experiencing hair loss and is using oral finasteride, considering adding RU58841 and microneedling, and planning a hair transplant. They are seeking advice on whether to wait for treatment results or proceed with the transplant.

      community Hair loss steps, guide to beginners or anyone experiencing hair loss

      in Treatment  1 upvotes 2 months ago
      The conversation discusses a hair loss treatment regimen involving finasteride, dutasteride, spironolactone, bicalutamide, oral estradiol, microneedling, and minoxidil. The regimen aims to reduce androgenic alopecia by blocking DHT and androgens, with a caution about potential feminizing effects.

      community Hair loss 30F - thoughts on red light therapy vs min/fin?

      in Female  6 upvotes 2 months ago
      The conversation discusses hair loss treatments for a 30-year-old female, comparing red light therapy with minoxidil and finasteride. Concerns about hormonal impact and potential pregnancy are raised, with suggestions to consider spironolactone and microneedling, while emphasizing the importance of consulting a dermatologist.

    Similar Research

    5 / 1000+ results