Detection of Subtypes of T Helper Cells and Their Cytokines in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Their Clinical Significances

    January 2014 in “ Journal of Jilin University ”
    Lin Zhao
    TLDR Higher levels of certain immune cells and proteins are linked to more severe lupus symptoms.
    The study investigated the changes and clinical significance of T helper cell subtypes (Th22, Th17, and Th1) and their cytokines in the peripheral blood of 30 patients with systemic lupus erythematosus (SLE) compared to 30 healthy controls. It found that the ratios of Th22, Th17, and IL-22+Th1 cells, as well as the levels of plasma IL-22 and IL-17, were significantly higher in SLE patients. There was a positive correlation between Th17 and Th22 cell ratios and between Th22 cell ratios and plasma IL-22 levels. Increased ratios of IL-22+CD4+T and IL-22-Th17 cells correlated with higher disease activity scores. Th22 cell ratios were higher in patients with facial erythema, hair loss, and positive anti-nuclear antibody (ANA), while Th17 cell ratios were higher in patients with light allergies or positive anti-dsDNA. The study concluded that IL-22+CD4+T cells, particularly Th22 cells and their cytokine IL-22, played a crucial role in SLE pathogenesis and could serve as biomarkers for disease severity.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Hair Loss “Cure” for Inflammation: Topical Roflumilast

      in Research/Science  33 upvotes 2 days ago
      Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

      community Hair loss stack thoughts? New to this!

      in Treatment  2 upvotes 5 days ago
      The conversation is about a hair loss treatment plan involving finasteride, minoxidil, microneedling, GHK-CU injections, Nizoral shampoo, and RU58841. The user is advised to start with a simpler regimen to minimize side effects and assess effectiveness before adding more treatments.

      community Hair loss over a year following depression and taking antidepressants

      in Side effects?  202 upvotes 1 week ago
      A 33-year-old experienced significant hair loss after a depressive episode and taking paroxetine, possibly due to telogen effluvium or androgenic alopecia. Suggestions included reducing alcohol, considering finasteride and minoxidil, and consulting a doctor about antidepressant side effects.

      community Hair loss journey - progress check & questions

      in Progress Pictures  1 upvotes 1 week ago
      The user shared their hair loss journey, using Minoxidil 2%, Serenoa repens, topical finasteride, a topical antiandrogen, Vitamin D, and lifestyle changes, noting improvements but still seeking more density. They are considering switching to Minoxidil 5% but prefer focusing on finasteride and antiandrogen for better results.

      community Hair loss & coffee consumption — curious about your experience

      in Chat  12 upvotes 2 weeks ago
      People shared their experiences with coffee consumption and hair loss, with mixed results. Some noticed more hair loss with increased caffeine, while others saw no effect or even hair regrowth, often using treatments like finasteride and minoxidil.

      community Hair loss help- on minoxidil and finasteride

      in Minoxidil  3 upvotes 2 weeks ago
      A 26-year-old male is using oral minoxidil and finasteride to treat hair loss, experiencing prolonged shedding despite 6 months of treatment. Others share similar experiences, suggesting persistence with the treatment may eventually lead to improvement.

    Similar Research

    5 / 1000+ results