TLDR No single biomarker is reliable enough for diagnosing and assessing SLE.
This study investigated biochemical and immunological biomarkers in 35 SLE patients and 35 healthy controls. The results showed significantly higher percentages of discoid rash, malar rash, photosensitivity, anemia, proteinuria, and leukopenia in SLE patients. Hair loss and nervous system involvement were not significantly higher. Anti-dsDNA was the most prevalent characteristic (33%), followed by blood urea (13%), hematuria (12%), and renal involvement (12%). Elevated levels of ANA and Anti-dsDNA were particularly noted. The study concluded that no single biomarker is sensitive or specific enough for SLE diagnosis and assessment.
39 citations,
October 2018 in “Lupus Science & Medicine” Different types of hair loss in lupus need careful diagnosis for proper treatment.
33 citations,
January 2011 in “Elsevier eBooks” Systemic Lupus Erythematosus has varied symptoms and is hard to diagnose, affecting many body parts and requiring careful clinical judgment.
109 citations,
November 2004 in “Lupus” The paper concludes that the 1982 criteria for diagnosing systemic lupus erythematosus need updating to improve accuracy and involve dermatologists in the process.
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1 citations,
April 2016 in “Journal of Reproductive Health and Medicine” Diagnosing new systemic lupus during pregnancy is hard but important for the health of the mother and baby.
December 2023 in “Curēus” A woman with lupus had rare severe symptoms but improved with treatment.
32 citations,
September 1989 in “Medical Clinics of North America” Skin problems are common in lupus, important for diagnosis, and can be triggered by sunlight.
