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In this study, researchers differentiated human induced pluripotent stem cells into dermal papilla-like cells and observed gene expression dynamics during five stages of dermal differentiation, demonstrating the potential of these cells to interact with epidermal cells in functional assays.

This study suggests that interfollicular epidermal keratinocytes with stem-like features may serve as an alternative to follicular keratinocytes for hair regeneration by supporting hair follicle morphogenesis in vivo.

In this study, l-Ascorbic acid 2-phosphate was found to stimulate hair follicle growth in vitro by promoting IGF-1 expression via the PI3K pathway.

In this study, researchers developed a chemical cocktail and suspension culture method to transform human dermal fibroblasts into dermal papilla-like cells capable of inducing hair follicle formation in vitro and in vivo.

This study found that both dental pulp-derived and hair follicle-derived mesenchymal stem cells showed similar stemness properties and differentiation potential, but hair follicle-derived cells exhibited superior differentiation into insulin-producing cells, suggesting their potential for autologous stem cell therapy in diabetes.

This study observed that storing hair follicle micrografts significantly decreased the expression of certain key genes in the dermal papilla, potentially affecting hair follicle cycling during preparation and storage.

In this study, researchers differentiated induced pluripotent stem cells into cells with dermal papilla-like properties, demonstrating their potential role in hair follicle bioengineering and drug testing for hair growth.

This study suggests that human induced pluripotent stem cells can be used to generate dermal papilla equivalent cells, potentially aiding hair follicle regeneration and drug discovery for hair diseases.

The study demonstrated that bulge stem cells from rat vibrissa follicles respond to adult dermal papilla signals, inducing hair bulb formation and regenerating hair structures in vivo.

This study found that conditioned medium from keratinocytes improved the hair-inductive properties of cultured dermal papilla cells, suggesting potential for enhancing hair follicle regeneration.

This study found that dermal papilla-like tissue reconstructed using canine adipose-derived mesenchymal stem cells closely resembles actual canine dermal papilla cells in both morphology and molecular characteristics.

In this study, cinnamic acid was found to enhance hair growth in human dermal papilla cells and hair follicle organoids by activating oxytocin signaling, suggesting its potential for developing hair growth-promoting products.

This review explores the potential (neuro-)endocrine influences on hair follicle epithelial stem cell biology and emphasizes the need for more systematic research, but it provides no new empirical results.

This study found that a 3D Matrigel culture technique for dermal papilla cell spheroids can enhance hair follicle inductivity and induce hair-like fiber differentiation in vitro, even with high-passage cells.

This study found that in mice, inactivating beta-catenin in the dermal papilla reduces hair follicle progenitor proliferation and disrupts the hair cycle.

This study demonstrates the use of microscopy-guided laser ablation to create a highly structured 3D hydrogel-based organotypic skin model with folliculoid structures, potentially useful for studying hair follicle development or bioactive substance screening.

In this study, adenosine was found to stimulate hair follicle growth in vitro by promoting growth factor expression, β-catenin activation, and downstream signaling pathways.

This study found that hyaluronic acid increased the size of hair follicle germ-like aggregates and the number of proliferative cells but did not maintain specific markers during the process.

Skin cells can help create early hair-like structures in lab cultures.

This study found that IGF1, retinoic acid, and dexamethasone increase IGFBP-3 production in cultured human dermal papilla cells, potentially inhibiting IGF1 action on hair growth.

This study found that while extracellular matrix components like hyaluronic acid promoted larger organoid formation, other matrix components hindered hair follicle germ assembly in an in vitro model.

This study found that 3D cultured hair follicle-like constructs, which include keratinocytes and dermal papilla cells, showed improved gene expression and cell interactions relevant to hair follicle development.

This study found that human dermal papilla cells are embedded in a basement membrane-like extracellular matrix, which is essential for their aggregation and function, as supported by evidence that Matrigel enhances dermal papilla cohesion and gene expression compared to collagen I, which promotes cell dispersion.

This study found that dermal papilla and dermal sheath cells from human scalp tissue differ from interstitial dermal fibroblasts in morphology and produce varying levels of TGF-beta 2.

This study found that using ionic liquid for specimen preparation allowed for observation of dermal papilla cells and their cilia in near-living conditions, reducing damage typically caused by conventional preparation methods.

The study suggests that culturing adipose-derived mesenchymal stem cells into spheroids with Wnt exposure can result in cell clusters resembling hair follicle dermal papilla cells, potentially aiding hair follicle generation.

This study demonstrated that elevated GABA levels can worsen stress-induced hair growth inhibition in mice, while GABAA antagonists like ginkgolide A may help alleviate these effects.

This review discusses the regenerative potential of hair follicle stem cell populations and current approaches to reconstructing folliculogenesis for alopecia therapy, but reports no new clinical results.

This study found that loliolide enhanced hair growth-related functions in 3D dermal papilla spheroids by activating AKT/β-catenin signaling pathways, with increased expression of related growth factors and genes.

This research discusses a novel imaging approach in live mice to study stem cell and niche interactions in tissue homeostasis and reports no new results.