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Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

Both drugs lower DHT levels, with GI198745 being more effective.

Finasteride helps treat hair loss and prostate enlargement by blocking a specific enzyme.

The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.

Puerariae Flos extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

A plant mixture extract helped grow hair by boosting cell growth and growth factors while blocking a hair loss-related enzyme.

Many elderly women experience unwanted facial hair and various hair loss conditions, with treatments available for each condition.

Some supplements and hormones can increase hair loss by raising DHT levels.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Targeting CXXC5 and GSK-3β may help treat male pattern baldness.

High testosterone to epitestosterone ratio in hair could predict male-pattern baldness.

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.

Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.

Docosahexaenoic acid (DHA) may help hair growth by promoting dermal papilla cell proliferation.

Blocking androgen activity in newborn rats affects body weight and appetite-related hormones differently in males and females.

Avicennia marina extract and avicequinone C can potentially promote hair growth and treat hair loss by interfering with hair loss mechanisms and boosting growth factors.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Testosterone makes the connections in the uterus lining simpler and lowers certain protein levels, which might lead to infertility.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.

5α-reductase inhibitors help treat disorders caused by DHT and have potential for future therapies.

Androgens, like DHT, affect hair growth and treatments like finasteride may help.

Blocking the protein CXCL12 with a specific antibody can increase hair growth in common hair loss conditions.

Topical finasteride might help with male hair loss with fewer side effects than pills, but more research is needed.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Blocking a protein called CXXC5 with a specific peptide can stimulate hair regrowth and new hair growth in wounds.