Mechanism of Salutary Effects of Finasteride on Post-Traumatic Immune/Inflammatory Response

November 2007 in “ Annals of Surgery ”

Michael Frink, Ya-Ching Hsieh, Shunhua Hu, Chi-Hsun Hsieh, Hans-Christoph Pape, Mashkoor A. Choudhry, Martin G. Schwacha, Kirby I. Bland, Irshad H. Chaudry

finasteride dihydrotestosterone DHT estrogen cytokines immune response inflammation sex hormone levels Propecia

TLDR Finasteride reduces inflammation and improves immune response after trauma by altering hormone levels.

This study investigated the effects of finasteride, a drug used to treat hair loss, on the immune response after trauma-hemorrhage in rats. The results showed that pretreatment with finasteride prevented the production of certain cytokines and decreased lung inflammation. Finasteride also decreased levels of dihydrotestosterone (DHT) and increased levels of estrogen, suggesting that the salutary effects of finasteride were mediated by increased estrogen concentration. The study suggests that modulation of sex hormone levels could be useful in developing new therapeutic strategies for patients with multiple injuries. However, it remains unknown whether treatment with finasteride after trauma-hemorrhage would have any salutary effects on immune responses.

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Research cited in this study

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research Androgen Receptor-Mediated Inhibition of Cutaneous Wound Healing

207 citations, September 2002 in “The Journal of clinical investigation/The journal of clinical investigation”

Blocking testosterone speeds up wound healing in males.

A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride

research A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride

60 citations, December 1998 in “Clinical Pharmacology & Therapeutics”

Both drugs lower DHT levels, with GI198745 being more effective.

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community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 7 months ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 1 month ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community Testosterone and DHT levels through the roof yet has better hair than the majority of guys who are “healthy” genetics are everything

in Satire 554 upvotes 1 year ago

The conclusion of this conversation about hair loss is that genetics play a significant role in determining hair loss, and specific treatments like finasteride may not be effective against certain compounds like masteron and trenbolone.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 158 upvotes 11 months ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community Why is it that low testosterone causes hair loss as well? How can I be balding?

in Chat 158 upvotes 7 months ago

The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 month ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

Related Research

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research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.