TLDR Ethosomes are a promising method for treating hair loss by delivering drugs directly to the scalp.
The document discussed the potential of ethosomes, which are ethanolic vesicular carriers, for treating androgenic alopecia by delivering drugs directly to the scalp's pilosebaceous unit. Ethosomes enhanced drug permeation across the skin, encapsulating both hydrophilic and lipophilic drugs with high entrapment efficiencies (~90%) and stability over long periods. They were found to be generally safe and cost-effective, though limited to transdermal applications and could cause allergic reactions in some patients. Studies showed that finasteride-loaded ethosomes effectively delivered the drug, preventing testosterone conversion to DHT, and ethosomes containing herbal extracts showed no toxicity and maintained stability for 4 years. The authors concluded that ethosomes are a promising drug delivery system for treating androgenic alopecia.
7 citations,
October 2017 in “Artificial Cells Nanomedicine and Biotechnology” Finasteride-loaded ethosomes improve hair loss treatment by targeting pilosebaceous unit.
9 citations,
June 2014 in “British Journal of Dermatology” The study found that balding scalps have more thin hairs and larger oil glands, which might contribute to skin conditions related to hair loss.
38 citations,
December 2010 in “Fertility and Sterility” Finasteride may cause male infertility, stopping it can help.
151 citations,
November 2018 in “International Journal of Pharmaceutics” Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.
151 citations,
July 2011 in “Archives of Dermatological Research” Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.
10 citations,
April 2016 in “Research and reports in transdermal drug delivery” Transfollicular drug delivery is promising but needs more research to improve and understand it better.
10 citations,
May 2021 in “Expert Opinion on Drug Delivery” Coenzyme Q10 vesicular formulations can potentially treat androgenic alopecia by promoting hair growth and thickness.
111 citations,
March 2012 in “Expert Opinion on Drug Delivery” Liposomes could improve how skin care products work but are costly and not very stable.
