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research Proceedings of the Ninth World Congress for Hair Research 2015
The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.
![PRC1 Fine-Tunes Gene Repression and Activation to Safeguard Skin Epithelium Development and Stem Cell Specification](/images/research/993c02f2-6f2b-4c32-848d-9d1e3fe7b6b4/small/19450.jpg)
research PRC1 Fine-Tunes Gene Repression and Activation to Safeguard Skin Epithelium Development and Stem Cell Specification
PRC1 is essential for proper skin development and stem cell formation by controlling gene activity.
![Complementary Evolution of Coding and Noncoding Sequence Underlies Mammalian Hairlessness](/images/research/386dfaec-3ef4-48b7-bda7-21cfff3a3d9d/small/30464.jpg)
research Complementary Evolution of Coding and Noncoding Sequence Underlies Mammalian Hairlessness
Hairlessness in mammals is caused by combined changes in genes and regulatory regions.
![Hair Follicle Growth and Pigmentation During Aging](/images/research/d1cf1b3c-d5df-4927-a100-3d9063caceb9/small/19441.jpg)
research Hair Follicle Growth and Pigmentation During Aging
The research found that a specific skin cell type not only triggers hair growth but also controls hair color, and that aging can lead to hair loss and color changes.
research Complementary Evolution of Coding and Noncoding Sequence Underlies Mammalian Hairlessness
Hairless mammals evolved quickly in both gene and non-gene areas related to skin and hair.
![Regulation of BMP Signaling in Melanogenesis, Pigment Transfer, and Melanocyte Migration](/images/research/499f3f96-fc70-4ff4-a263-45fd4c42153b/small/19438.jpg)
research Regulation of BMP Signaling in Melanogenesis, Pigment Transfer, and Melanocyte Migration
BMP signaling is important for skin color, affecting melanin production, pigment spread, and cell movement.
![Hair Growth Induced by Blockade of Macrophage-Derived Oncostatin M and Downstream JAK-STAT5 Signaling in Hair Follicle Stem Cells](/images/research/1ef6ccf4-61a9-42c8-876f-5acdb36ebcbe/small/19453.jpg)
research Hair Growth Induced by Blockade of Macrophage-Derived Oncostatin M and Downstream JAK-STAT5 Signaling in Hair Follicle Stem Cells
Blocking a specific immune cell signal can trigger hair growth.
![A Novel Cell Surface Marker for Hair Follicle Dermal Cells Throughout Hair Morphogenesis and Cycling](/images/research/093000c7-2d23-404d-8e66-88beacf81eee/small/19448.jpg)
research A Novel Cell Surface Marker for Hair Follicle Dermal Cells Throughout Hair Morphogenesis and Cycling
Researchers found that the Leptin receptor is a consistent marker for hair follicle dermal cells, which may help future hair research.
![The Role of Fgf20 in Establishing the Hair Follicle Dermal Condensate](/images/research/095f6598-3042-4191-9eb6-b3d09395c9f7/small/19452.jpg)
research The Role of Fgf20 in Establishing the Hair Follicle Dermal Condensate
Fgf20 is important for the development and regulation of the cells that form the base of hair follicles.
![MicroRNA Control of Signal Transduction](/images/research/f6ae6a85-76d3-43b1-a05b-2d911627dd82/small/19906.jpg)
research MicroRNA Control of Signal Transduction
MicroRNAs are crucial in controlling cell signaling, affecting cancer and tissue regeneration.
![Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats](/images/research/b2b9e8eb-f8a1-4776-ac9a-2a36f54c4682/small/3412.jpg)
research Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats
![Fibroblast Growth Factors: Key Players in Regeneration and Tissue Repair](/images/research/b946dae7-6f60-48f8-b740-e7cbf39b2f80/small/12751.jpg)
research Fibroblast Growth Factors: Key Players in Regeneration and Tissue Repair
Fibroblast Growth Factors (FGFs) are important for tissue repair and regeneration, influencing cell behavior and other factors involved in healing, and are crucial in processes like wound healing, bone repair, and hair growth.
![Convergent Genesis of an Adult Neural Crest-Like Dermal Stem Cell from Distinct Developmental Origins](/images/research/125d6d1f-c30a-4841-a900-415c3006f3d5/small/33031.jpg)
research Convergent Genesis of an Adult Neural Crest-Like Dermal Stem Cell from Distinct Developmental Origins
Skin-derived precursors in hair follicles come from different origins but function similarly.
![Roles of Jumonji and Jumonji Family Genes in Chromatin Regulation and Development](/images/research/59f92c66-c23a-4e2c-bea5-5567d7e3090c/small/20000.jpg)
research Roles of Jumonji and Jumonji Family Genes in Chromatin Regulation and Development
Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.
![Skin Transcriptome Profiling of Changthangi Goats Highlights the Relevance of Genes Involved in Pashmina Production](/images/research/5c6a81ab-b8a6-4ffe-b73d-389a01fcd6fd/small/28992.jpg)
research Skin Transcriptome Profiling of Changthangi Goats Highlights the Relevance of Genes Involved in Pashmina Production
Changthangi goats have specific genes that help produce Pashmina wool.
![Integration of Ethylene and Auxin Signaling and the Developmental Consequences of Their Crosstalk](/images/research/86096334-0858-43e4-a9aa-af579772603d/small/21758.jpg)
research Integration of Ethylene and Auxin Signaling and the Developmental Consequences of Their Crosstalk
Ethylene and auxin hormones interact in complex ways that are essential for plant growth and development.
![Integration Analysis of Transcriptome and Proteome Reveals the Mechanisms of Goat Wool Bending](/images/research/da2efcf4-2ba2-4426-b300-49a71186bb53/small/32965.jpg)
research Integration Analysis of Transcriptome and Proteome Reveals the Mechanisms of Goat Wool Bending
The research identified key proteins and genes that may influence wool bending in goats.
![Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)](/images/research/c72e0003-03d6-4afc-82a7-7b779ea469fc/small/30782.jpg)
research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)
Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.
![The Hairless Gene of the Mouse: Relationship of Phenotypic Effects with Expression Profile and Genotype](/images/research/e36101d0-9c14-4466-8605-d02429f1e1f3/small/20047.jpg)
research The Hairless Gene of the Mouse: Relationship of Phenotypic Effects with Expression Profile and Genotype
Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.
![Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)](/images/research/d4bbf5a1-c540-478c-84bb-1db426fc5839/small/30816.jpg)
research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)
The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.
research Defects in Androgen Biosynthesis Causing 46,XY Disorders of Sexual Development
Genetic defects in androgen production are linked to male developmental disorders and are improving treatment understanding.
![How a Bird Gets Its Feathers: Insights from Chromatin Looping](/images/research/82fbbf7c-8717-4c7c-a5b7-1b3277f3ab93/small/17461.jpg)
research How a Bird Gets Its Feathers: Insights from Chromatin Looping
Feather patterns are influenced by enhancers and chromatin looping, and the structure of protein complexes important for hair growth has been detailed.
![Abstract 151](/images/research/81e01e75-5722-45b3-8c1e-9418f54032cf/small/19677.jpg)
research Abstract 151
Activating TLR3 helps improve skin and hair follicle regeneration after wounds.
![Abstract 152](/images/research/825704e2-80c9-4e78-ae24-55e9b9e311e4/small/19678.jpg)
research Abstract 152
TLR3 activation helps improve skin and hair follicle healing in mice.
![Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation](/images/research/f34c09a0-8d4a-4e0c-a306-6361ab32f3b7/small/29472.jpg)
research Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation
The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.
![Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat](/images/research/452b2c6a-5f11-4f9e-9540-6588c9542a7e/small/19292.jpg)
research Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat
DNA methylation and long non-coding RNAs are key in controlling hair growth in Cashmere goats.
![Integrated Analysis of miRNAs and mRNA Profiling Reveals the Potential Role of miRNAs in Sheep Hair Follicle Development](/images/research/0c0d284d-7f5f-4d79-bbb3-811fd98b5ff2/small/32945.jpg)
research Integrated Analysis of miRNAs and mRNA Profiling Reveals the Potential Role of miRNAs in Sheep Hair Follicle Development
Certain miRNAs may play a role in sheep hair follicle development, which could help improve wool production.
![Uncombable Hair Syndrome and Beyond](/images/research/f4d44d87-eae3-4a3e-bb1c-2cd3d62f6a44/small/13019.jpg)
research Uncombable Hair Syndrome and Beyond
Uncombable hair syndrome causes frizzy hair and can affect the nervous system, eyes, and ears, often co-occurring with other hair, skin, nail, and teeth conditions, and is linked to three specific gene mutations.
![Melatonin Promotes Proliferation of Inner Mongolia Cashmere Goat Hair Follicle Papilla Cells Through Wnt10b](/images/research/c54ae1a5-0b71-4554-986e-d1244107098e/small/26918.jpg)
research Melatonin Promotes Proliferation of Inner Mongolia Cashmere Goat Hair Follicle Papilla Cells Through Wnt10b
Melatonin helps grow cashmere goat hair by activating the Wnt10b gene.