TLDR cDermo-1 causes dense skin, feathers, and scales in chickens.
The study demonstrated that misexpression of the transcription factor cDermo-1 in chick embryos induced the formation of dense dermis, ectopic feather buds, and scales, even in normally featherless regions. This indicated that cDermo-1 is a key regulator of early skin appendage development, acting upstream of β-catenin and FGF-10. The research, conducted on 20 chick embryos using a retroviral expression vector, provided insights into the molecular mechanisms of skin morphogenesis and the potential for gene manipulation in influencing skin structure formation.
745 citations,
February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
4 citations,
June 2023 in “Journal of developmental biology” The skin systems of jawed vertebrates evolved diverse appendages like hair and scales from a common structure over 420 million years ago.
October 2024 in “Biology” Dermal papilla cells can help regrow hair and are promising for hair loss treatments.
82 citations,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
115 citations,
December 2017 in “Wiley Interdisciplinary Reviews-Developmental Biology” Skin cells called dermal fibroblasts are important for skin growth, hair growth, and wound healing.
3 citations,
August 2023 in “Genes” The document concludes that various signaling pathways and genetic factors are crucial for chicken feather development, affecting poultry quality.
