TLDR cDermo-1 causes dense skin, feathers, and scales in chickens.
The study demonstrated that misexpression of the transcription factor cDermo-1 in chick embryos induced the formation of dense dermis, ectopic feather buds, and scales, even in normally featherless regions. This indicated that cDermo-1 is a key regulator of early skin appendage development, acting upstream of β-catenin and FGF-10. The research, conducted on 20 chick embryos using a retroviral expression vector, provided insights into the molecular mechanisms of skin morphogenesis and the potential for gene manipulation in influencing skin structure formation.
745 citations
,
February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
4 citations
,
June 2023 in “Journal of developmental biology” The skin systems of jawed vertebrates evolved diverse appendages like hair and scales from a common structure over 420 million years ago.
October 2024 in “Biology” Dermal papilla cells can help regrow hair and are promising for hair loss treatments.
82 citations
,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
115 citations
,
December 2017 in “Wiley Interdisciplinary Reviews-Developmental Biology” Skin cells called dermal fibroblasts are important for skin growth, hair growth, and wound healing.
3 citations
,
August 2023 in “Genes” The document concludes that various signaling pathways and genetic factors are crucial for chicken feather development, affecting poultry quality.
