Transcriptome Profiling of Human Follicle Dermal Papilla Cells in Response to Porphyra-334 Treatment by RNA-Seq
January 2021
in “
Evidence-based complementary and alternative medicine
”
porphyra-334 mycosporine-like amino acid collagen synthesis fibroblast cells keratinocyte cells human follicle dermal papilla cells metallothionein-associated genes antioxidant hair follicle cycle epidermal structure stem cells collagen fibroblasts keratinocytes HFDP cells antioxidants hair cycle skin structure
TLDR Porphyra-334 may help reduce wrinkles and promote hair growth.
The study investigated the effects of porphyra-334, a mycosporine-like amino acid with ultraviolet-A absorbing properties, as an antiaging agent. In vitro assays showed that porphyra-334 significantly increased collagen synthesis in fibroblast cells and cell viability, particularly in keratinocyte cells. An in vivo clinical test involving 22 participants suggested that porphyra-334 could improve periorbital wrinkles. RNA-sequencing of human follicle dermal papilla (HFDP) cells treated with porphyra-334 revealed upregulation of metallothionein-associated genes, indicating its antioxidant role, and genes related to nuclear chromosome segregation and kinetochore components. Additionally, genes linked to the hair follicle cycle, structure, epidermal structure, and stem cells were also upregulated, pointing to porphyra-334's potential in promoting hair follicle growth and maintenance. The study provided evidence supporting porphyra-334's use as an antiaging cosmetic agent and its impact on gene expression in HFDP cells.
