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This chapter reviews laboratory models used for studying alopecia therapies but provides no new experimental findings.

This study found that extracellular vesicles from stimulated human dermal fibroblasts enhanced hair follicle growth ex vivo by activating dermal papilla cells and involving the Norrin and β-catenin pathways.

This study found that vanillic acid from wheat bran promoted dermal papilla cell proliferation, potentially stimulating hair growth by activating the PI3K/Akt and Wnt/β-catenin pathways.

This study observed that dermal papilla cell aggregates showed increased viability and gene expression on softer 3D substrates, indicating the importance of substrate stiffness in cellular behavior.

This study found that all-trans-retinoic acid (ATRA) inhibits mink hair follicle growth by reducing dermal papilla cell proliferation and inducing apoptosis, likely through the TGF-β2/Smad2/3 pathway.

This study examined the effects of WNT10B on dermal papilla cells in vitro, finding that it alters gene expression, decreases protein synthesis, and upregulates a specific signaling pathway, potentially influencing hair follicle morphogenesis.

This study demonstrated that caffeine, minoxidil, and the HIF-1α-stimulating agent deferiprone significantly enhanced dermal papilla cell proliferation in a 3D culture model, suggesting deferiprone as a potential alternative to minoxidil.

This study found that endothelin produced by hair follicle progenitors activates contractions in dermal sheath cells, facilitating hair follicle regression in the growth cycle.

This study successfully developed 3D hair follicle organoids from neonatal mouse epidermal and dermal cells, showing structural and molecular resemblance to native anagen hair follicles.

In this study, researchers observed that Vdr-knockout mice experience hair cycle arrest during the catagen stage, leading to alopecia, with persistent epithelial strands forming in the hair follicles, indicating Vitamin D receptor's role in regulating hair follicle regression and regeneration.

This study identifies key transcriptomic features and a necessary dermal niche for eccrine gland development, advancing potential regenerative approaches for these vital skin appendages.

This study used multi-scale hybrid models to explore how signaling factors affect skin wound healing and embryo development, suggesting that different levels of fibrin clot density influence scar formation.

This study reports that incorporating Lef-1 transfected dermal papilla cells into human skin equivalents significantly promoted hair follicle differentiation and hair fiber growth, offering a potential advancement for managing skin loss.

In laboratory studies on mice, Abstract UT-018, a stem cell chemoattractant formulation, was reported to significantly enhance wound healing and promote hair regeneration through mechanisms involving improved tissue formation, collagen organization, and follicular development.

This study found that alkyl shikimates with different alkyl group structures can increase or decrease fibroblast proliferation depending on concentration and alkyl chain length, with some variants showing cytotoxic effects due to their hydrophobicity and cell membrane permeability.

In this study, oral administration of blue honeysuckle fruit extract was found to promote hair growth in mice by enhancing dermal papilla cell proliferation and activating β-catenin signaling, suggesting its potential use as a food or cosmetic product for hair regeneration.

This review highlights the potential of bioengineered dermal scaffolds in tissue engineering to enhance wound healing by mimicking the dermal structure and supporting cellular processes, while also discussing recent advancements and challenges in scaffold technology.

This study found that mesenchymal cells from adult mouse whisker follicles differentiated into odontoblast-like cells, demonstrating odontogenic potential in a specialized microenvironment both in vitro and in vivo.

In a testosterone-induced mouse model, this study found that exosomes from injectable Platelet-Rich Fibrin (i-PRF) significantly reduced inflammation, oxidative stress, and apoptosis, while enhancing hair regeneration, with the greatest improvements seen when combined with minoxidil, suggesting potential as a novel treatment for androgenetic alopecia.

This study found that topical transplantation of green fluorescent protein-labeled bone marrow mesenchymal stem cells significantly improved regeneration of deeper wounds, with increased blood vessel formation, compared to control in a rat model.

In this study, researchers found that a scallop adhesive protein (Sbp9 Δ) forms strong adhesive coatings via disulfide-sticker strategies, which also promote hair regeneration in mouse models by activating Wnt signaling and enhancing angiogenesis, proving more effective than minoxidil for androgenetic alopecia.

This study discovered that adipose tissue infiltration at the isthmus level appears significantly more often in frontal fibrosing alopecia cases compared to controls, suggesting a potential role in the condition's pathology.

This study found that in stretch-mediated tissue expansion, fibroblasts adopt an embryonic-like, low-collagen state that enhances epidermal stem cell renewal, supporting coordinated skin expansion crucial for reconstructive surgeries.

This article reviews how environmental factors and aging contribute to skin and hair changes, including wrinkling, dryness, pigmentation changes, and hair thinning, but reports no new research findings.

New treatments for cancer and skin disorders show promise in disrupting harmful cell interactions and promoting hair growth.

This study found that Ng2+ perivascular cells in mouse skin are a diverse lineage-restricted population primarily recruited from papillary or reticular fibroblast lineages during wound healing, maintaining heterogeneity in both wounded and non-wounded skin.

This study highlights exosome-based therapies as promising treatments for androgenetic alopecia, detailing protocol development, quality control measures, and clinical application examples, with mesenchymal stem cell-derived exosomes improving hair density in a case study without adverse effects.

New treatments may restore cancer-blocking proteins, slow prostate cancer, identify drug targets, and potentially regrow hair.

The researchers reported that they predicted associations between certain components of MSC-conditioned medium and its ability to stimulate cell migration in vitro, identifying factors affecting its biological activity.

In this study, human bone marrow mesenchymal stem cell-derived exosomes significantly accelerated cutaneous wound healing in rats by modulating the TGF-β/Smad signaling pathway.