Topical Transplantation of Bone Marrow Mesenchymal Stem Cells Enhances Regeneration of Deeper Skin Wounds

    October 2020 in “ Plastic Surgery ”
    Yonghong Qin, Li Aishu, Yazan Al-Ajam, Yu‐Ting Liao, Zhang Xuanfeng, Jin Zhang
    TLDR Bone marrow stem cells improve healing of deep skin wounds.
    The study investigated the effects of topical transplantation of bone marrow mesenchymal stem cells labeled with green fluorescent protein (BM-MSCs/GFP) on wound healing in a model using 120 Sprague Dawley rats. The research aimed to assess wound regeneration at varying depths, from epidermal to full-thickness dermal loss. Results showed that BM-MSCs/GFP transplantation significantly improved the regeneration of deeper wounds, extending the regeneration depth from the infundibulum apex (control group) to the opening site of the sebaceous duct at the hair follicle level. This group also exhibited normal skin appearance and less wound contraction compared to controls. Additionally, the BM-MSCs/GFP group had higher expression of vascular endothelial growth factor (VEGF) and an increased number of blood vessels, indicating enhanced angiogenesis. These findings suggested that BM-MSCs/GFP could effectively promote deeper wound healing and reduce scarring.
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