Topical Transplantation of Bone Marrow Mesenchymal Stem Cells Enhances Regeneration of Deeper Skin Wounds

    October 2020 in “ Plastic Surgery ”
    Yonghong Qin, Li Aishu, Yazan Al-Ajam, Yu‐Ting Liao, Zhang Xuanfeng, Jin Zhang
    TLDR Bone marrow stem cells improve healing of deep skin wounds.
    The study investigated the effect of green fluorescent protein-labeled bone marrow mesenchymal stem cells (BM-MSCs/GFP) on wound healing in a model with varying wound depths using 120 Sprague Dawley rats. The results showed that BM-MSCs/GFP transplantation significantly improved the regeneration of deeper wounds compared to the control group. In the BM-MSCs/GFP group, regeneration extended to the opening site of the sebaceous duct at the hair follicle, resembling normal skin with less wound contraction. Additionally, the expression of vascular endothelial growth factor (VEGF) and the number of blood vessels were significantly higher in the BM-MSCs/GFP group, indicating enhanced healing.
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