Exosome-Based Therapies: Protocol Development for Androgenetic Alopecia

Exosome-based therapies are emerging as promising treatments for androgenetic alopecia (AGA) by modulating dermal papilla biology and the perifollicular niche through pathways like Wnt/β-catenin and VEGF. This article discusses protocol development, emphasizing donor screening, manufacturing standardization, and clinical application parameters. A case study of a 45-year-old male showed improvement from 75 to 110 hairs/cm² after 3 sessions of microneedling with exosomes, without adverse events. The authors highlight the need for standardized protocols and recommend multicenter trials to ensure reproducibility and safety, suggesting that exosome therapy could become a viable alternative or adjunct to current AGA treatments.