Subcutaneous Injection of Genetically Engineered Exosomes for Androgenic Alopecia Treatment

May 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”

Yukun Liu (800466), Yonghong Liu (542108), Jing Zhao (21160), Tianyi Deng (14000838), Yinyin Ben (144465), Ruitao Lu (11458904), Xusha Zhou (8750790), Runbin Yan (14000844), Xiaoqing Chen (89898), Jian V. Zhang (10860855), Grace Zhou (15141228)

androgenetic alopecia genetically engineered exosomes EX104 HEK-293 cells WNT10B VEGFA FGF7 DHT dermal papilla cells hair follicle miniaturization murine model follicular microenvironment minoxidil capillary growth follicular proliferation AGA hair loss hair growth Rogaine

TLDR EX104 effectively promotes hair growth and regenerates follicles in androgenetic alopecia.

The study investigates a novel treatment for androgenetic alopecia (AGA) using a genetically engineered exosome-based delivery platform called EX104. Developed from HEK-293 cells, EX104 expresses therapeutic molecules like WNT10B, VEGFA, and FGF7, which reverse hair follicle miniaturization caused by DHT-induced dermal papilla cells. In a murine model, EX104 significantly promoted hair growth by remodeling the follicular microenvironment and restoring miniaturized follicles. It showed comparable hair growth effects to minoxidil but was superior in stimulating capillary growth and follicular proliferation, making EX104 a promising strategy for AGA management and follicular regeneration.

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