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The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.

Higher androstenedione levels in women with PCOS are linked to more severe symptoms.

Certain drugs that block specific enzymes can help treat prostate diseases.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

New genes and pathways are important for testosterone production and male sexual development.

Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.

Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

Statins may help treat PCOS by lowering androgen levels and improving cholesterol.

New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Genes and epigenetic changes are important in the development of Polycystic Ovary Syndrome.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Blocking the FGF5 gene in sheep leads to more fine wool and active hair follicles due to changes in certain cell signaling pathways.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

DHT in the human prostate is produced through multiple pathways, not just from testosterone.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

Hormones and genes affect hair growth and male baldness.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

New liposome treatment successfully delivers CRISPR to deactivate a key enzyme in androgen-related disorders.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.