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Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Androgen use may increase the risk of stroke, but more research is needed.

A new mutation in the CYP11B1 gene was found in a woman with mild hyperandrogenemia, a rare cause of non-classic congenital adrenal hyperplasia.

Borneol Essential Oil could be a natural and safe acne treatment.

DNA methylation changes in women with PCOS could be used as disease markers and suggest new treatment targets.

CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.

Gene mutations can cause problems in male genital development.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Minoxidil may work for hair loss by reducing androgen sensitivity and altering hormone-related enzymes.

Baicalin may help reduce excessive male hormone levels in PCOS.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

MicroRNAs could be key biomarkers and therapeutic targets for PCOS.

Men with baldness have higher levels of specific proteins, suggesting local hormone production may play a role in hair loss.

Glioblastoma cells can make androgens, which might help the tumor grow.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

Don't combine abiraterone and spironolactone for prostate cancer treatment as it may worsen the disease.

Rare adrenal cancers that secrete androgens or estrogens have a poor prognosis and are treated primarily with surgery.

DHT, a testosterone byproduct, causes male pattern baldness.

New treatments targeting androgen receptors show promise for drug-resistant prostate cancer.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Oxidative stress worsens PCOS by damaging cells and disrupting metabolism, suggesting antioxidant treatments might help.

A new method accurately measures nine specific hormones in human blood.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.