17-Hydroxyprogesterone Responses to Gonadotropin-Releasing Hormone Reveal Distinct Phenotypes of Functional Ovarian Hyperandrogenism and Polycystic Ovary Syndrome

    September 2007 in “ The Journal of Clinical Endocrinology and Metabolism ”
    Renato Pasquali, Laura Patton, Patrizia Pocognoli, Graciela Estela Cognigni, Alessandra Gambineri
    Image of study
    TLDR The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.
    In 2007, Pasquali et al. conducted a study on 148 women with polycystic ovary syndrome (PCOS) and 22 healthy controls to investigate the role of functional ovarian hyperandrogenism (FOH) in PCOS. They found that PCOS could be divided into two phenotypes based on the 17-hydroxyprogesterone response to the GnRH agonist buserelin: a normal-response PCOS group (NR-PCOS, n = 78) and a high-response PCOS group (HR-PCOS, n = 70). The HR-PCOS group had more severe hyperandrogenemia, higher basal testosterone, free androgen index, 17-hydroxyprogesterone, estrogens, insulin, and C-peptide levels, and lower insulin sensitivity compared to the NR-PCOS group. The study concluded that FOH is not specific to all women with PCOS and that insulin may play a role in the overactivation of the CYP17 enzyme pathway in women with HR-PCOS, leading to more severe hyperandrogenemia and insulin resistance. This suggests that there are distinct clinical and metabolic phenotypes within PCOS.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 815 results

      community 17 month finasteride update (title)

      in Progress Pictures  51 upvotes 3 weeks ago
      The user has been using finasteride since November 2023, which improved their hair and confidence, and they plan to switch to dutasteride and get a hair transplant. They noticed hair thickening after 3-4 months on finasteride and are considering oral dutasteride and minoxidil for further improvement.

      community *17 month update*Before & after pic.

      in Progress Pictures  540 upvotes 3 weeks ago
      The conversation discusses a user's impressive hair regrowth progress over 17 months using a topical minoxidil and finasteride spray from HIMS, with suggestions to add microneedling for better results. Some users express skepticism about the authenticity of the results, while others inquire about side effects and application methods.

      community 17-Month Update - Dut, Min, Niz, 1.5mm roller.

      in Progress Pictures  312 upvotes 1 year ago
      A 39-year-old shared a 17-month hair loss treatment update using Dutasteride, Minoxidil, Nizoral shampoo, and a 1.5mm derma roller, noticing significant results after 9-12 months. They also maintain a healthy lifestyle and manage side effects like dry skin with moisturizer.

      community 17 month update 30M FUT 2300 grafts 1 year fin/min topical

      in Progress Pictures  414 upvotes 1 year ago
      A user shared a 17-month update on their hair loss treatment, which included a hair transplant of 2300 grafts, using a topical solution of minoxidil and finasteride, a laser cap, and ketoconazole shampoo. They are considering another transplant and seeking honest feedback on their progress, while others share their own experiences and advice on hair loss treatments.

    Similar Research

    5 / 1000+ results
      Gonads

      research Gonads

      November 2013 in “John Wiley & Sons, Ltd eBooks”
      The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.
      Polycystic Ovary Syndrome in Adolescents

      research Polycystic Ovary Syndrome in Adolescents

      18 citations, April 2016 in “Endocrinology and Metabolism Clinics of North America”
      The document concludes that diagnosing PCOS in teenagers is difficult and should focus on specific hormone levels and menstrual irregularities, while also considering treatment for symptoms and related health issues.
      Adult Polycystic Ovary Syndrome Begins in Childhood

      research Adult Polycystic Ovary Syndrome Begins in Childhood

      124 citations, June 2002 in “Best Practice & Research Clinical Endocrinology & Metabolism”
      Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.