17-Hydroxyprogesterone Responses to Gonadotropin-Releasing Hormone Reveal Distinct Phenotypes of Functional Ovarian Hyperandrogenism and Polycystic Ovary Syndrome

    September 2007 in “ The Journal of Clinical Endocrinology and Metabolism ”
    Renato Pasquali, Laura Patton, Patrizia Pocognoli, Graciela Estela Cognigni, Alessandra Gambineri
    Image of study
    TLDR The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.
    In 2007, Pasquali et al. conducted a study on 148 women with polycystic ovary syndrome (PCOS) and 22 healthy controls to investigate the role of functional ovarian hyperandrogenism (FOH) in PCOS. They found that PCOS could be divided into two phenotypes based on the 17-hydroxyprogesterone response to the GnRH agonist buserelin: a normal-response PCOS group (NR-PCOS, n = 78) and a high-response PCOS group (HR-PCOS, n = 70). The HR-PCOS group had more severe hyperandrogenemia, higher basal testosterone, free androgen index, 17-hydroxyprogesterone, estrogens, insulin, and C-peptide levels, and lower insulin sensitivity compared to the NR-PCOS group. The study concluded that FOH is not specific to all women with PCOS and that insulin may play a role in the overactivation of the CYP17 enzyme pathway in women with HR-PCOS, leading to more severe hyperandrogenemia and insulin resistance. This suggests that there are distinct clinical and metabolic phenotypes within PCOS.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 694 results

    Similar Research

    5 / 1000+ results
      Gonads

      research Gonads

      November 2013 in “John Wiley & Sons, Ltd eBooks”
      The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.
      Polycystic Ovary Syndrome in Adolescents

      research Polycystic Ovary Syndrome in Adolescents

      18 citations, April 2016 in “Endocrinology and Metabolism Clinics of North America”
      The document concludes that diagnosing PCOS in teenagers is difficult and should focus on specific hormone levels and menstrual irregularities, while also considering treatment for symptoms and related health issues.
      Adult Polycystic Ovary Syndrome Begins in Childhood

      research Adult Polycystic Ovary Syndrome Begins in Childhood

      124 citations, June 2002 in “Best Practice & Research Clinical Endocrinology & Metabolism”
      Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.