April 2019 in “Journal of Investigative Dermatology” This study found that induced COX-2 expression in adult transgenic mice led to hair follicle miniaturization and enlargement of sebaceous glands, and suggests that targeting the PGD2 pathway might reverse these effects.
February 2018 in “Biophysical Journal” This study found that cyclosporine A can alter lipid bilayer properties and does so at a slower rate, suggesting conformational shifts may facilitate its membrane crossing.
September 2016 in “Journal of dermatological science” This study suggests that FGF18 may enhance radioresistance in telogen hair follicles by inducing cell cycle arrest, potentially serving as a radioprotector against radiation-induced hair follicle damage.
May 2015 in “Journal of The American Academy of Dermatology” This study presents an algorithm that may help physicians diagnose female hair loss by synthesizing patient history, clinical examination, and various diagnostic tests.
November 2012 in “The Journal of Urology” Certain gene variants may raise the risk of prostate enlargement, but taking NSAIDs could reduce this risk.
April 2010 in “Cancer Research” This study found that altering CDK4 expression in mice affects the population of keratinocyte stem cells, suggesting a correlation with susceptibility to skin papillomas.
January 2010 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study concluded that monthly pulse IV cyclophosphamide is effective for severe lupus nephritis in Indian patients, achieving complete or partial remission in 68.9% of cases, though longer follow-up is needed.
January 2010 in “Chinese Medical Journal of Metallurgical Industry” This study found that leflunomide combined with prednisone showed good efficacy and tolerance in treating lupus nephritis where cyclophosphamide was ineffective or intolerable.
January 2008 in “Pratique médicale & chirurgicale de l'animal de compagnie” This review discusses the controversial non-inflammatory alopecia known as alopecia X, highlighting its unknown etiology and the variable effectiveness of various proposed treatments, but reports no new results.
This study found that the enzyme encoded by Dgat1 acts as a retinol acyltransferase in murine epidermis, protecting against retinoid toxicity and alopecia by preventing retinol accumulation.
January 2003 in “Reactions Weekly” Lowering the dose of cyclosporin caused hair loss that didn't improve even when the dose was increased again.
January 2003 in “Journal of Clinical Dermatology” This study found that cyclosporin A stimulated hair growth in mouse vibrissae follicles by promoting cell proliferation, reducing apoptosis, and altering the expression of certain growth factor mRNAs.
January 2002 in “대한피부과학회지” This study found that oral cyclosporine combination therapy led to new hair growth in 71% of patients with severe and refractory alopecia areata, though mild and transient side effects were common.
January 2000 in “Linchuang pifuke zazhi” This study demonstrated that cyclosporin A upregulated mRNA expression of HGF and VEGF in cultured mouse vibrissa follicles.
July 1995 in “Journal of Dermatological Science” Cyclosporine starts hair growth faster, while minoxidil makes it last longer.
August 1994 in “Journal of dermatological science” Cyclosporin A and FK506 can start new hair growth in mice, but ascomycin and rapamycin cannot.
August 1994 in “Molecular Endocrinology” This study found that AtT-20 pituitary cells with higher cAMP-dependent kinase activity had larger calcium currents and significantly increased beta-endorphin release compared to cells with lower kinase activity.
August 1993 in “Journal of Dermatological Science” Cyclosporin and minoxidil promote hair growth.
April 2021 in “Journal of Investigative Dermatology” This study developed a transgenic mouse model to explore androgenetic alopecia, finding that inducible COX2 expression led to sebaceous gland changes and hair miniaturization, with reversible effects upon reducing COX2.
July 2008 in “British Journal of Dermatology” Cyclosporin doesn't stop hair loss.
835 citations
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October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
499 citations
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September 2011 in “Cell” This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.
375 citations
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February 2006 in “Journal of Cell Science” This article reviews the stages and regulation of the hair cycle, highlighting molecular regulators involved, but it does not present new research findings.
277 citations
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June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.
215 citations
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September 2003 in “Journal of Biological Chemistry” This study found that the hairless gene product (Hr) suppresses VDR-mediated gene activation by directly interacting with the vitamin D receptor, potentially affecting hair follicle function.
212 citations
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September 2015 in “Journal of Investigative Dermatology” This article presents a comprehensive guide for classifying human hair follicle cycle stages in vivo using scalp xenografts on immunocompromised mice, offering valuable resources for researchers in the field.
211 citations
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April 2013 in “Development” In this study, researchers found that the number of dermal papilla cells in hair follicles determines hair size and shape in mice, suggesting potential avenues for addressing hair loss.
169 citations
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May 2006 in “Genes & Development” This study found that keratin 17 and TNFα play interdependent roles in regulating hair follicle cycling, with TNFα required for the anagen–catagen transition and its ablation partially rescuing hair cycling defects in K17-null mice.
158 citations
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February 2012 in “Journal of Investigative Dermatology” FGF18 helps keep hair in its resting phase, affecting hair growth cycles.
155 citations
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August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution” This review discusses the conserved molecular mechanisms controlling hair follicle development and cycling and suggests they may also apply to other ectodermal derivatives, like teeth and feathers, but it reports no new results.