152 citations
,
December 2003 in “Micron” This review discusses the development, regulation, and aging of the human hair follicle pigmentary system and suggests potential for reversing hair graying by manipulating follicle melanocytes in vitro, but reports no clinical results.
149 citations
,
June 2010 in “The FASEB journal” In this study, miR-31 was found to play a significant role in hair cycle regulation in mice by controlling key gene expressions involved in hair growth and differentiation.
146 citations
,
May 2002 in “The American journal of pathology” This study found that cathepsin L deficiency in mice led to significant abnormalities in hair follicle development and cycling, including disrupted hair shaft outgrowth and premature hair growth phase entry.
130 citations
,
January 1994 in “Differentiation” In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.
127 citations
,
December 2007 in “Journal of Investigative Dermatology” This review examines regenerative hair waves and complex hair cycle domains in transgenic mice, highlighting how these dynamic processes contribute to skin regeneration and the physiological regulation of organs, but reports no new experimental results.
116 citations
,
May 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study discovered that the circadian clock influences hair follicle regeneration, making hair grow faster in the morning and causing more radiation-induced hair loss in the morning compared to the evening.
112 citations
,
February 2001 in “Journal of Investigative Dermatology” This study found that substance P and calcitonin-gene-related peptide have different roles in regulating hair growth in mice, with substance P promoting anagen progression and calcitonin-gene-related peptide inhibiting it.
111 citations
,
March 1951 in “Annals of the New York Academy of Sciences” This article discusses the hair cycle of mice and its relevance in studying experimental carcinogenesis sequences, but it reports no new research findings.
109 citations
,
December 1998 in “The Journal of Dermatology” This review discusses the hair follicle cycle's complex regulation and highlights the potential for targeting catagen control in future therapies without presenting new experimental data.
109 citations
,
April 1997 in “Archives of Dermatological Research” The researchers reported that mast cell and nerve fiber interactions in mouse skin are highly selective for nerve fiber types and vary depending on the hair cycle phase.
103 citations
,
January 2006 in “Journal of Cell Science” This review summarizes the major events and regulators of the hair cycle in mammals but reports no new experimental results; it emphasizes the complex regulation of stem cell activation and differentiation during hair growth.
98 citations
,
July 2006 in “Neuropsychopharmacology”
97 citations
,
March 2002 in “Molecular and cellular biology” This study found that mice with a mutant CDP/Cux protein lacking the homeodomain showed severely impaired growth, high postnatal mortality, and reduced fertility, highlighting CDP/Cux's role in developmental regulation.
95 citations
,
July 2006 in “British Journal of Dermatology” This study observed that vitamin D receptor expression in certain hair follicle cells varies throughout the murine hair cycle, suggesting a potential role for 1,25-dihydroxyvitamin D3 in hair follicle biology.
92 citations
,
September 2013 in “Journal of Investigative Dermatology” This study found that peripheral clock genes, particularly BMAL1 and Period1, modulate human hair follicle cycling, suggesting their potential as therapeutic targets for affecting hair growth.
92 citations
,
November 2006 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that transgenic mice overexpressing the BMP antagonist noggin showed increased hair follicle size and altered hair type, linked to changes in cell proliferation and gene expression.
92 citations
,
February 2005 in “Endocrinology” This study found that estrogen receptor beta plays a significant role in murine hair growth control, potentially acting as a silencer of estrogen receptor alpha's catagen-promoting effects.
91 citations
,
May 2003 in “American Journal of Pathology” This study found that prolactin and its receptor are expressed in the murine hair follicle epithelium, influencing hair cycle phases by down-regulating keratinocyte proliferation during anagen and inducing premature catagen.
88 citations
,
May 2005 in “Journal of Dermatological Science” In this study, specific versican expression was observed in the anagen phase of human hair follicles, suggesting its importance in maintaining normal hair growth.
86 citations
,
December 2001 in “Experimental dermatology” This review classifies mutant mice with hair abnormalities into six categories, providing an annotated table that serves as a reference for understanding the molecular controls of hair growth.
86 citations
,
August 2000 in “Pigment cell research” This study observed that melanogenesis in human hair follicles is linked to anagen phases, with melanocyte activity and enzyme expression being region-specific to the nascent bulb.
81 citations
,
January 2003 in “The FASEB Journal” This study found that follistatin and activin interactions are important for hair follicle development and cycling in mice, suggesting that they may regulate processes involving BMP-2 and its antagonist.
74 citations
,
January 2013 in “Expert Opinion on Biological Therapy” This review discusses recent advances in hair follicle biology, regeneration, and tissue engineering, highlighting emerging therapeutic opportunities, and reports no new experimental results.
73 citations
,
November 2000 in “Proceedings of the National Academy of Sciences of the United States of America” This study demonstrated that anagen can be induced in Stat3-disrupted mice, suggesting that both Stat3-dependent and independent pathways, possibly involving PKC, mediate hair cycle progression with required PI3K activation.
69 citations
,
May 1997 in “Veterinary Pathology” This study found that the angora mouse mutation prolongs the anagen phase, resulting in excessively long hair and follicular abnormalities, without involving circulating hair cycle factors.
68 citations
,
April 2012 in “Journal of Investigative Dermatology” The study reports that Fgf18 and Tgf-β2 signaling pathways in hair follicle stem cells have opposing effects on the timing of hair cycle transitions, influencing the shift from telogen to anagen phases.
67 citations
,
July 2000 in “Proceedings of the National Academy of Sciences” This study developed a follicular automaton model that simulates human hair cycle dynamics and can replicate hair pattern changes associated with diffuse or androgenetic alopecia.
67 citations
,
July 1985 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that males have significantly longer hair on their thighs compared to females, mainly due to a longer anagen phase and a greater rate of growth.
66 citations
,
June 2010 in “Experimental Dermatology” This paper argues that the cycling hair follicle serves as a valuable model for systems biology research, highlighting its potential for translational medicine.
64 citations
,
October 1998 in “Acta dermato-venereologica” This study found that proanthocyanidins from grape seeds significantly promote hair follicle cell proliferation and hair cycle transition in mice, suggesting their potential as hair growth agents.