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    Glossary CXCL3

    protein that attracts immune cells to inflammation sites

    CXCL3 is a type of protein known as a chemokine, which plays a role in the immune system by attracting white blood cells to sites of inflammation or injury. It is involved in various biological processes, including wound healing and the response to infections, and can influence conditions like alopecia by affecting the local immune environment around hair follicles.

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    1. CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17 The Journal of Experimental Medicine · 2024 · 32 citations
    2. CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata Journal of Immunology · 2016 · 64 citations
    3. The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles Differentiation · 2009 · 57 citations
    4. Increased Circulating CXCL10 in Non-Segmental Vitiligo Concomitant with Autoimmune Thyroid Disease and Alopecia Areata Annals of Dermatology · 2019 · 17 citations
    5. Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population Genetics and Molecular Research · 2015 · 8 citations
    6. Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing Frontiers in Immunology · 2024 · 7 citations
    7. Combination of an engineered <i>Lactococcus lactis</i> expressing CXCL12 with light‐emitting diode yellow light as a treatment for scalded skin in mice Microbial biotechnology · 2021 · 6 citations
    8. Th1 Chemokine CXCL10 and Alopecia Areata: The Possible Target for the Treatment of Alopecia Areata Journal of Clinical & Cellular Immunology · 2016 · 3 citations
    9. Author response: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis 2019 · 1 citations
    10. Insights into the context-dependent immunological roles of the CXCL12–CXCR4 axis in alopecia Frontiers in Immunology · 2026
    11. Hypoxia-Derived Mesenchymal Stem Cell Exosomes Downregulate CXCL12 and Upregulate IL-10 Expression in a Murine Model of Androgenic Alopecia Molecular and Cellular Biomedical Sciences · 2026
    12. Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration Cell Reports · 2025
    13. CXCL12 Drives Reversible Fibroimmune Remodeling in Androgenetic Alopecia Revealed by Single-Cell RNA Sequencing International Journal of Molecular Sciences · 2025
    14. EVALUATION OF THE ROLE OF CXCL12 IN CASES OF ALOPECIA AREATA ALEXMED ePosters · 2025
    15. Differential Expression of CXCL12 in Human and Mouse Hair: Androgens Induce CXCL12 in Human Dermal Papilla and Dermal Sheath Cup International Journal of Molecular Sciences · 2024
    16. CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata International Journal of Molecular Sciences · 2024
    17. CXCL12 inhibits hair growth through CXCR4 Biomedicine & Pharmacotherapy · 2022
    18. Decision letter: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis 2019
    19. Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice Experimental and Therapeutic Medicine · 2017
    20. Correlation Analysis of CXCL10, FOS, HOXC13, and WNT4 Gene Polymorphisms with Key Economic Traits—Initial Population Screening for Jiangnan Cashmere Goats Genes · 2025
    21. Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis EMBO molecular medicine · 2022 · 9 citations
    22. PRF Lysates Modulate Chemokine Expression in Oral Squamous Carcinoma and Healthy Epithelial Cells Bioengineering · 2024 · 2 citations
    23. A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle Frontiers in Immunology · 2025 · 1 citations
    24. Hyperinnervation inhibits organ-level regeneration in mammalian skin Cell · 2026
    25. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    26. Rapid skin repigmentation on oral ruxolitinib in a patient with coexistent vitiligo and alopecia areata (AA) Journal of the American Academy of Dermatology · 2015 · 157 citations
    27. Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair Nature Communications · 2016 · 86 citations
    28. The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1 New England Journal of Medicine · 2024 · 71 citations
    29. Treatment of an alopecia areata patient with tofacitinib results in regrowth of hair and changes in serum and skin biomarkers Experimental Dermatology · 2016 · 70 citations
    30. Type 1 interferon signature in the scalp lesions of alopecia areata British Journal of Dermatology · 2010 · 52 citations