Th1 Chemokine CXCL10 and Alopecia Areata: A Possible Target for Treatment

    January 2016 in “ Journal of Clinical & Cellular Immunology ”
    Taisuke Ito, Toshiharu Fujiyama, Y. Tokura
    TLDR Targeting CXCL10 may help treat alopecia areata.
    The study explored the role of the Th1-associated chemokine CXCL10 in alopecia areata (AA), an autoimmune disease characterized by hair loss. It was found that in acute-phase AA, hair follicles expressed high levels of CXCL10, attracting CXCR3+CD4+ and CXCR3+CD8+ T cells, which contributed to the "swarm of bees" appearance around hair bulbs. In chronic-phase AA, CXCR3+CD8+ T cells dominated, potentially prolonging hair loss. The study suggested that targeting the chemotactic activity of CXCL10 could be a novel treatment approach for AA. Antihistaminic drugs like olopatadine showed potential in reducing this chemotactic activity by affecting CXCR3 expression and related cellular processes.
    Discuss this study in the Community →

    Research cited in this study

    15 / 15 results

    Related Community Posts Join

    6 / 1000+ results

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community How does dutasteride regrowth work?

      in Finasteride/Dutasteride  6 upvotes 7 months ago
      A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  142 upvotes 10 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 5 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

    Related Research

    3 / 3 results