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This review explores the potential of multifunctional bioscaffolds in skin tissue engineering, highlighting their successful biological performance in vitro and in vivo animal models, while also identifying the demand for technological advancements to improve wound healing applications in clinical settings.

This study describes a protocol for generating hair-bearing skin organoids from human pluripotent stem cells, achieving full complexity resembling fetal skin tissue by day 130 in vitro.

This review discusses the roles and mechanisms of glycosaminoglycans in wound healing and presents challenges and potential applications for GAG-based biomaterials without reporting new experimental results.

This review categorizes contractile hydrogels by their contraction mechanisms and explores their role in advanced wound management, emphasizing mechanical and biochemical signaling in healing, but also notes challenges like force transmission and clinical applicability.

This study found that Kangfuxin improved cell proliferation, migration, and wound healing in a mouse model of cutaneous injury through the activation of the STAT3 signaling pathway.

This review discusses the growing importance of hydrogel scaffolds in skin wound healing, highlighting their unique properties and recent advancements in their use for treating difficult tissue damage, particularly within tissue engineering.

This review discusses the potential of Pluronic F127-derived hydrogels for wound healing, examining their applications in various wound types and exploring underlying mechanisms and their interaction within the wound microenvironment.

This study introduces a new biomimetic double wound mask designed to promote scarless healing by coordinating multiple biological pathways and providing enhanced protection and nourishment to wounds.

This review discusses the integration of biodegradable biomaterials with drugs and stem cells for diabetic wound repair, but reports no new clinical results and highlights the need for further translation to clinical practice.

This review discusses the potential of mesenchymal stem/stromal cells and their exosomes in promoting wound healing and skin regeneration, but reports no new experimental results.

In this study, a hydrogel with anti-inflammatory, antibacterial, antioxidant, and wound tissue adhesion properties was developed, showing significant potential for wound healing and suggesting it could offer a new and effective treatment option in clinical settings.

This study reported that a newly developed hydrogel composed of recombinant type I collagen and chitosan, incorporating a metal–polyphenol structure, demonstrated strong mechanical and healing properties, effectively promoting wound healing in a full-thickness skin defect model.

This study found that injectable gelatin/metal/tea polyphenol double nanonetworks significantly accelerated wound healing in diabetic wounds by enhancing cell migration and providing anti-inflammatory and antioxidant properties, without detectable cytotoxicity in tests.

This review discusses the use of human-to-mouse xenografting to study human skin processes in vivo, highlighting its importance for understanding skin regeneration and pathology while identifying knowledge gaps and challenges in applying these findings to human skin.

This study demonstrated that implanting μm-scale full-thickness columns of human skin tissue into immunodeficient mice restored key features of normal human skin, suggesting potential for human wound repair with minimal donor site morbidity.

This review examines the regeneration capabilities of skin, oesophagus, and oral mucosa, highlighting the oral mucosa's unique scarless healing properties and the potential of cell therapy to improve scar reduction in wound healing.

This study highlights the versatility and potential of injectable hydrogel nanocomposites in biomedical research, emphasizing their roles in controlled drug delivery, tissue regeneration, and treatment of various conditions, such as cardiac issues, joint diseases, and bone regeneration.

This review explores advancements in bioprinting technologies for developing in vitro skin models that replicate immune-mediated skin diseases, highlighting their potential to reduce animal testing and enhance research and product testing capabilities in dermatology.

This review highlights recent advancements in engineered probiotics for wound healing, reporting that genetically engineered strains of Lactobacillus reuteri and Lactococcus cremoris have shown promise in promoting faster wound healing in pre-clinical and clinical settings, particularly for diabetic foot ulcers.

This study found that although three-dimensional bioprinting in plastic and reconstructive surgery is rapidly advancing, complete tissue systems have not yet been successfully printed due to ongoing challenges.

This review summarizes the current applications and mechanisms of self-assembled peptide hydrogels in promoting skin, bone, and nerve regeneration, highlighting their potential due to their biocompatibility and supportive role in tissue healing.

This study demonstrated that an AR-EGFP transgene can restore AR function and fertility in Sertoli cell-specific AR knockout mice, highlighting its potential use in understanding androgen receptor functions.

Cold Plasma shows promise for healing wounds by killing bacteria and helping tissue grow.

This review discusses the potential of extracellular vesicles for facial aesthetic applications, including scar reduction and skin rejuvenation, but reports no new clinical results; further research into production and mechanisms is needed.

This paper discusses the multipotency of cyst cells and proposes that understanding molecular circuits in cyst formation could enable engineering of desired stem cell culture phenotypes, but reports no new experimental outcomes.

This review reports that chitosan, a versatile polysaccharide, shows potential for various therapeutic applications due to its chemical modifications, notably in treating non-communicable diseases and wound healing, though further clinical study is needed to confirm these benefits.

In this study, researchers performed a genome-wide characterization of the Wnt gene family in domestic donkeys, identifying 19 genes and highlighting their evolutionary conservation among mammals, along with tissue-specific expression patterns potentially linked to reproductive regulation and tissue homeostasis.

This review highlights significant research trends and challenges in utilizing plant-derived extracellular vesicles for drug delivery and biomedical applications, emphasizing the need for standardized protocols and advanced purification technologies.

This review discusses recent advancements in microneedle technology for hair loss treatment, highlighting their ability to enhance drug delivery and improve hair follicle survival in transplantation, while also exploring their potential integration with tissue engineering to address regeneration challenges.

This study provides a comprehensive overview of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (HUCMSC-EVs), suggesting their potential to combat aging and alleviate age-related disorders by rejuvenating multiple organs in animal models and discussing engineering strategies to harness their full anti-aging potential.