Advances in Bioprinting to Model Immune-Mediated Skin Diseases

November 2025 in “ Advanced Healthcare Materials ”

Andrea Ulloa‐Fernández, Marica Marković, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov

bioprinting engineered skin tissue inflammatory skin diseases in vitro models 3Rs framework immune-mediated skin diseases

TLDR Bioprinting is improving skin models for better testing of skin diseases without using animals.

The document reviews recent advancements in bioprinting technologies for creating in vitro skin models to study immune-mediated skin diseases, such as psoriasis, atopic dermatitis, vitiligo, and alopecia areata. These models aim to replicate human skin's physiological and architectural features, incorporating immune components to better understand inflammatory responses. Techniques like Laser-Induced Forward Transfer (LIFT) and Digital Light Processing (DLP) enhance precision and scalability, allowing for the integration of vascularization and immune cells. Despite challenges in achieving full clinical translation, these bioprinted models offer promising alternatives to animal testing, aiding in drug discovery and therapeutic development for chronic, non-communicable inflammatory skin diseases.

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