May 2021 in “Our Dermatology Online” A woman with a rare scalp condition causing a thick scalp and hair loss didn't improve with steroid treatment.
August 2020 in “International Journal of Research in Dermatology” Clouston's syndrome is a rare disorder affecting nails, hair, teeth, and skin, caused by a gene mutation, and currently has no treatment, only supportive care.
112 citations,
August 2012 in “The American Journal of Human Genetics” The study identified mutations in the RBPJ gene in two families affected by Adams-Oliver Syndrome (AOS), a rare genetic disorder characterized by congenital scalp defects and limb anomalies. These mutations impaired the DNA binding ability of RBPJ, a key transcriptional regulator in the Notch signaling pathway, specifically in the HES1 promoter region. The findings provided new insights into the genetic basis of AOS, suggesting that RBPJ plays a crucial role in the development of the scalp and limbs, and highlighted the importance of genetic screening for accurate diagnosis and potential future therapies for AOS. The research was funded by an Oklahoma Medical Research Foundation Research Grant.
23 citations,
October 2021 in “Cell Stem Cell” Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.
13 citations,
November 2017 in “Journal of Cellular and Molecular Medicine” The workshop discussed the role of a protein called calreticulin in health and disease, its potential as a treatment target, and its possible use as a disease marker.
12 citations,
February 2023 in “Journal of Personalized Medicine” Type 1 diabetes often occurs with other autoimmune diseases, and personalized treatment based on genetics can improve outcomes.
6 citations,
September 2012 in “Our Dermatology Online” Retinoids are effective for various skin conditions and hair loss but have serious side effects, so low doses are recommended.
4 citations,
May 2020 in “Annals of palliative medicine” Plum blossom needle acupuncture with qi-invigorating therapy is more effective for Seborrheic Alopecia than Western medicine.
April 2024 in “Journal of translational medicine” Melanocytes are important for normal body functions and have potential uses in regenerative medicine and disease treatment.
September 2023 in “International Journal of Community Medicine and Public Health” Different sebaceous gland diseases can be treated with medications, hormone therapy, or surgical methods.
August 2023 in “Journal of Dermatological Treatment” Mesotherapy might improve hair growth, but more research is needed to confirm its safety and effectiveness.
January 2023 in “Open Journal of Endocrine and Metabolic Diseases” Hyperandrogenism is a common hormonal disorder in women, often linked to PCOS.
January 2017 in “Open Journal of Endocrine and Metabolic Diseases” The document concludes that managing Dunnigan-Type Familial Partial Lipodystrophy involves treating associated health issues and using medications like metformin and leptin replacement.
The conclusion is that there's a link between high testosterone levels, insulin resistance, and certain skin conditions, regardless of obesity.
194 citations,
November 2006 in “Science” A genetic mutation in the LIPH gene causes hair loss and growth defects.
96 citations,
August 1995 in “Bone” Vitamin D3 is important for bone health and may help treat various diseases beyond bone-related conditions.
81 citations,
September 2009 in “Birth defects research” Different body areas in mice produce different hair types due to interactions between skin layers.
49 citations,
November 2021 in “Annual review of pathology” Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.
35 citations,
December 2009 in “Differentiation” Desmoglein 4 is controlled by specific proteins that affect hair growth.
31 citations,
August 2021 in “Stem Cell Research & Therapy” The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
26 citations,
July 2016 in “Journal of biological chemistry/The Journal of biological chemistry” sPLA2-IIE is crucial for normal hair follicle structure and skin health.
24 citations,
December 2018 in “Inflammation and Regeneration” Phospholipase A2 enzymes play key roles in skin health and disease.
21 citations,
May 2019 in “Experimental Dermatology” Different fields of expertise must work together to better understand hair growth and create effective hair loss treatments.
9 citations,
March 2022 in “Frontiers in Endocrinology” About 19.4% of Iranian women in the study have Polycystic Ovary Syndrome, with the most common type involving irregular periods and high male hormone levels, but their heart and metabolic health is similar to women without the condition.
6 citations,
January 2019 in “F1000Research” High triglyceride levels are a key factor affecting testosterone levels in women with PCOS.
4 citations,
January 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” A faulty KLHL24 gene leads to hair loss by damaging hair follicle stem cells.
4 citations,
August 2018 in “Journal of pediatric neurology” Becker's Nevus Syndrome is a rare condition with a skin patch and possible bone and muscle abnormalities, treated mainly for appearance.
4 citations,
January 2016 in “Dermatology practical & conceptual” A man developed a rare skin condition after a hair transplant surgery.
4 citations,
May 2012 in “BMJ Case Reports” A Nigerian baby with neonatal lupus got better with treatment by 6 months.
3 citations,
March 2023 in “American journal of physiology. Cell physiology” Inward rectifier potassium channels are important in many body functions and diseases, and could be potential drug targets.