13 citations
,
February 2015 in “Journal of Pharmaceutical Sciences” This study found that the polymorphic forms I, II, and III of finasteride can be prepared purely, with form III being identical to what was previously referred to as form X.
12 citations
,
March 2020 in “Journal of Bioactive and Compatible Polymers” This study found that finasteride- and minoxidil-loaded nanoparticles in a gel improved skin permeability and drug retention, suggesting a promising approach for topical alopecia treatment with reduced dosing frequency and side effects.
11 citations
,
October 1994 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride increases hair growth, prolongs hair cycle, and lowers dihydrotestosterone levels.
10 citations
,
January 2015 in “The Journal of Clinical Pharmacology” In this study, no statistically significant association was found between finasteride use and the risk of acute pancreatitis in Taiwanese males aged 40-84.
10 citations
,
December 2014 in “Journal of Pharmaceutical and Biomedical Analysis” Finasteride's polymorphic form affects capsule quality and drug effect, requiring strict control.
9 citations
,
August 2012 in “Thermochimica Acta” In this study, researchers found that finasteride exhibits a solid-solid phase relationship that is enantiotropic at normal pressure and becomes monotropic at higher pressure.
9 citations
,
October 1993 in “The Journal of Clinical Pharmacology” Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.
7 citations
,
January 2019 in “The Aging Male” This article discusses post-finasteride syndrome as a distinct syndrome related to prolonged use of 5α-steroid reductase inhibitors, noting persistent side effects even after discontinuation and no new research results are reported.
7 citations
,
April 2015 in “General and Comparative Endocrinology” Finasteride negatively affects fish reproduction and gonadal development.
6 citations
,
February 2016 in “Journal of Microencapsulation” This study found that injectable finasteride microspheres provided a sustained drug release with a minimal initial burst in albino rabbits compared to oral suspension.
4 citations
,
July 2021 in “Journal of Dermatological Treatment” This meta-analysis reported that finasteride 1 mg/day significantly increased hair count in male androgenetic alopecia compared to placebo, but highlighted persistent sexual side effects and associated depression risk.
4 citations
,
January 2002 in “Indian Journal of Pharmaceutical Sciences” This study developed a precise and reproducible method for estimating finasteride in tablet formulations using a colorimetric reaction with specific reagents.
3 citations
,
April 2021 in “Journal of Medicinal Chemistry” This study suggests that finasteride may inhibit the enzyme PNMT, potentially contributing to its sexual and psychological side effects.
3 citations
,
October 2010 in “Wiley-VCH Verlag GmbH & Co. KGaA eBooks” Finasteride safely treats enlarged prostate and male-pattern baldness.
2 citations
,
January 2022 in “Rasayan journal of Chemistry” This study analyzed the affinity, stability, and pharmacokinetics of compounds from Sansevieria trifasciata, reporting that three compounds showed promising molecular docking results against the androgen receptor and satisfactory pharmacokinetic profiles, similar to minoxidil, in an in-silico setting.
2 citations
,
August 2016 in “Experimental Dermatology” This review discusses the efficacy and safety of oral finasteride for treating male pattern baldness and the potential persistent side effects, but no new results are reported.
2 citations
,
January 2012 in “Journal of The Chilean Chemical Society” This study developed and validated a precise RP-HPLC-PDA method for estimating finasteride in bulk and tablet forms, suitable for quality control use.
2 citations
,
October 2010 in “European Journal of Drug Metabolism and Pharmacokinetics” Researchers developed a quick and sensitive way to measure finasteride in blood using a small sample size.
2 citations
,
November 2008 in “Industrial & Engineering Chemistry Research” This study found that the presence of benzeneseleninic acid in commercial anhydride samples lowered the reaction rate during the oxidation of a finasteride intermediate compared to pure anhydride.
1 citations
,
December 2020 in “Journal of Chemical and Petroleum Engineering” The researchers in this experimental study developed a thermodynamic model using the Peng-Robinson equation of state to optimize gas antisolvent system conditions for controlling finasteride particle size, aiming to reduce experimental trials and precisely identify precipitation pressures across different temperatures.
1 citations
,
January 2017 in “Asian Journal of Chemistry” New method effectively analyzes finasteride and its stability.
In this case study, ischemic stroke occurred in a 20-year-old male taking finasteride for hair loss, with multiple genetic predispositions for thrombosis; while causality is uncertain, clinicians should exercise caution when prescribing finasteride to patients with thrombotic risk factors.
This study reviews existing literature on regenerative therapy for androgenetic alopecia, highlighting that integrating growth factors, biotin, D-pantenol, and other active ingredients using the Vittahair protocol may enhance hair follicle regeneration, increase hair density, and improve hair quality, providing a precise and evidence-based treatment alternative.
March 2023 in “Enciclopédia Biosfera” The researchers reported that finasteride was effective in controlling hormone-related dysfunction in an adult dog diagnosed with benign prostatic hyperplasia, although the condition regressed after the medication was withdrawn.
January 2022 in “Asian journal of Current Research in Clinical Cancer” This study reviews the potential of dibenzo derivatives as safer cancer treatments but finds conflicting evidence about their effectiveness, possibly due to structural differences among the compounds, and reports no new results.
August 2014 in “Acta Crystallographica” This study found that the dissolution profiles of different finasteride polymorphs may affect the quality of finasteride capsules, highlighting the need for polymorphic quality control.
29 citations
,
April 2004 in “Annals of Pharmacotherapy” This review concluded that finasteride may reduce hirsutism scores and hair diameter in women with hyperandrogenism, but concerns about teratogenicity and long-term safety make it a secondary treatment option.
20 citations
,
November 2019 in “Biomolecules” This study found that finasteride impaired stress reactivity and reduced exploratory and impulsive behaviors in rats, potentially by altering the hypothalamus-pituitary-adrenal axis function.
9 citations
,
August 2000 in “Journal of Periodontal Research” Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.
May 2019 in “Asian Journal of Chemistry” Finasteride forms three new products under acidic stress.