Phenomenology of Polymorphism: The Topological Pressure–Temperature Phase Relationships of the Dimorphism of Finasteride
August 2012
in “
Thermochimica Acta
”
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Studysummary In this study, researchers found that finasteride exhibits a solid-solid phase relationship that is enantiotropic at normal pressure and becomes monotropic at higher pressure.
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This paper discusses the phase behavior of finasteride, an active pharmaceutical ingredient used in the treatment of benign prostatic hyperplasia. The study focuses on the two polymorphs of finasteride and their relationship with temperature and pressure. The authors demonstrate that with basic calorimetric measurements and X-ray diffraction, a complete topological pressure-temperature phase diagram can be constructed. The paper concludes that a complete picture of the relative stability between two polymorphs should be described as a function of temperature and pressure.
