Polymorphism
September 2008
TLDR Different crystal forms of drugs can change their effectiveness.
The document discussed various examples of polymorphism in pharmaceutical compounds, highlighting how different crystalline forms can affect the properties and efficacy of drugs. It included specific cases such as Indomethacin, Sulindac, Losartan, Finasteride, Ibuprofen Lysinate, and others, illustrating the significance of polymorphic forms in drug development and performance. The chapter also mentioned the phase rule and phase transitions as fundamental concepts in understanding polymorphism. The future direction section likely addressed potential advancements or research areas in the study of polymorphism in pharmaceuticals.
