TLDR Different crystal forms of drugs can change their effectiveness.
The document discussed various examples of polymorphism in pharmaceutical compounds, highlighting how different crystalline forms can affect the properties and efficacy of drugs. It included specific cases such as Indomethacin, Sulindac, Losartan, Finasteride, Ibuprofen Lysinate, and others, illustrating the significance of polymorphic forms in drug development and performance. The chapter also mentioned the phase rule and phase transitions as fundamental concepts in understanding polymorphism. The future direction section likely addressed potential advancements or research areas in the study of polymorphism in pharmaceuticals.
11 citations
,
February 2004 in “Clinical and Experimental Ophthalmology” Taking Propecia might lead to the development of cataracts.
June 2024 in “Georgetown medical review” Finasteride treats hair loss but may cause low libido, erectile issues, and depression.
June 2017 in “Reactions Weekly” Finasteride (Propecia) may cause depression and suicidal thoughts; stop use and inform a healthcare professional if symptoms develop.
3 citations
,
June 2004 in “Annales De Dermatologie Et De Venereologie” Four new cases of gynecomastia (male breast enlargement) linked to finasteride (Propecia) have been found.
2 citations
,
January 2003 in “Journal of Clinical Dermatology” 1 mg finasteride can cause reversible painful breast enlargement in men.
April 2012 in “Reactions Weekly” Finasteride may cause more sexual side effects than previously thought.
