Isolation and Structural Characterization of Degradation Products of Finasteride by Preparative HPLC, HRMS, and 2D NMR

    June 2019 in “ Asian Journal of Chemistry ”
    Santhosh Guduru, V.V.S.R.N. Anji Karun Mutha, B. Vijayabhaskar, Muralidharan Kaliyaperumal, Prabhakar S. Achanta, Sreenivasa Reddy Anugu, Bharath Komandla, Raghu Babu Korupolu, Kishore Babu Bonige, Chidananda Swamy Rumalla
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    TLDR Finasteride forms three new products under acidic stress.
    The study investigated the stability of finasteride under different stress conditions and found that it produced three new degradation products under acidic stress. These products were isolated and their structures were determined using various analytical techniques. All three products were found to be novel.
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