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This review outlines the development, applications, and challenges of microneedle-based drug delivery from 2000-2019, particularly highlighting fabrication techniques, but reports no new clinical results.

This research reported that squarticles, nanoparticles made from sebum-derived lipids, enhanced the follicular delivery and skin accumulation of diphencyprone and minoxidil, indicating effective drug deposition with reduced systemic absorption in alopecia treatment.

This study found that IMT-P8, a novel cell-penetrating peptide, effectively facilitated the dermal delivery of proteins and peptides in mouse skin and cell lines, suggesting potential for topical applications in cosmetics and skin diseases.

In this study, polymeric micelles containing retinoic acid were found to improve targeted delivery to hair follicle structures in human skin more efficiently than a marketed retinoic acid gel, suggesting potentially safer and more effective acne treatment.

This study found that nanostructured lipid carriers with more soybean phosphatidylcholine provided better skin retention and follicular targeting for diphencyprone compared to other formulations and controls.

This study found that increasing a drug's lipophilicity and adding ethanol to the donor phase can enhance its delivery to the hair follicle, although the precise transport mechanism remains unclear.

This study found that skin microbiota, particularly in wild-type mice, promotes wound-induced hair follicle neogenesis and wound healing, highlighting the potential downsides of routine antibiotic use on skin regeneration.

This study demonstrated that a mechanical-assisted post-bioprinting strategy significantly increased cell numbers and enhanced regenerative capabilities in hollow hydrogel-based scaffolds for bone defect repair in vivo.

This review discusses recent advancements in understanding hair follicles, their disorders, and potential therapeutic opportunities, but it reports no new clinical findings.

This study demonstrated effective delivery of CRISPR/Cas9 components to dermal papilla cells in androgenic alopecia animals using ultrasound-activated nanoparticles, resulting in specific gene editing and hair growth recovery.

This study found that self-noncoding dsRNA activates TLR3 to stimulate intrinsic retinoic acid synthesis, promoting new hair follicle formation in wounded mice and showing similar gene expression changes in humans treated with rejuvenation lasers.

This study found that 'black dots' seen under trichoscopy are not specific to alopecia areata and may occur in various other hair and scalp conditions.

In this study, researchers developed a wearable red and blue LED patch and a sprayable fibrin gel to treat infected wounds at home, demonstrating effective infection control and enhanced wound healing in diabetic mice and minipigs.

This study found that massaging the skin significantly increases follicular penetration of liposomes in an ex vivo setting, while occlusion only enhanced penetration for rigid liposomes.

This review explores research on nanoformulations for enhancing the topical delivery of herbal medicines, noting potential benefits like improved bioavailability and sustained delivery, and emphasizes the need for safety and toxicity guidelines in developing these novel drug delivery systems.

This study found that fibromodulin significantly reduces scar formation and boosts scar strength in rodent and porcine models, suggesting potential for FMOD-based therapies in cutaneous wound repair.

This study found that nobiletin-loaded vesicles effectively restored skin condition in a mouse model of skin cancer, suggesting they are a promising treatment delivery system.

This review highlights the need for methodologies to understand and quantify drug penetration into hair follicles as significant drug pathways, noting this area lacks comprehensive articles and reports no new results.

In this study, the authors concluded that arabinogalactan proteins recognized by specific antibodies are involved in the differentiation and development of barley root epidermal cells, contributing to root hair development.

This study found that Er–YAG laser treatment significantly enhanced skin absorption and follicular delivery of antialopecia drugs, suggesting a potential laser-assisted approach to treat alopecia.

This study reported that nanoemulsions significantly improved the skin permeability of thiocolchicoside compared to its aqueous solution, suggesting they are effective carriers for its transdermal delivery.

This study reported that oleic acid-based nanovesicles improve follicular delivery and reduce side effects of minoxidil compared to traditional MXD lotions.

This study achieved a first by successfully forming large quantities of dermal papilla spheroidal microtissues, which retained their hair induction potential, using a micropatterned culture system.

This review summarizes findings on the use of ethosomes for enhanced transdermal drug delivery and reports no new clinical results.

Bimatoprost can cause longer, thicker, darker eyelashes and eyebrows.

This study found that using layer-by-layer encapsulation techniques on dermal papilla cells can support their function and may help treat hair loss when used in conjunction with freshly isolated epidermal cells.

This study found that encapsulated Garcinia mangostana Linn extract in a cream base penetrated more deeply and homogeneously into porcine ear skin compared to other formulations.

This study found that gelatin microspheres delivering adipose-derived stem cells significantly accelerated diabetic wound healing in rats, suggesting a promising approach for enhancing cell-based therapies.

This study found that SA-MS hydrogel released Mo4+ ions which promoted healing of disease-impaired wounds by enhancing cell proliferation and angiogenesis, and through its photothermal effects addressed skin cancer-impaired wounds in mice.

This study investigated a liposomal hydrogel system for delivering minoxidil and tretinoin to treat androgenic alopecia, finding that the system enhanced skin permeation of minoxidil while retaining tretinoin on the skin and was non-irritating in animal tests, suggesting its potential effectiveness.