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    Glossary Chromatin Accessibility

    degree to which DNA is exposed for cellular processes

    Chromatin accessibility refers to how easily DNA can be reached and read by cellular machinery. In simple terms, it's like how open a book is: if the pages are tightly closed, it's hard to read, but if they're open, it's easy. For professionals, it indicates the degree to which chromatin structure allows transcription factors and other proteins to interact with DNA, influencing gene expression and cellular function.

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    1. DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation Science advances · 2023 · 3 citations
    2. TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network Advanced Science · 2026
    3. 1440 DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control keratinocyte differentiation and hair growth 2023
    4. 723 DNA dioxygenases Tet2/3 regulate gene promoter accessibility and three-dimensional chromatin topology in lineage-specific loci to control hair growth 2022
    5. States and Fates of Skin Fibroblasts Revealed through Chromatin Accessibility Journal of Investigative Dermatology · 2022
    6. Profiling Chromatin Accessibility at Single-Cell Resolution Genomics Proteomics & Bioinformatics · 2021 · 52 citations
    7. Single-cell chromatin landscapes of mouse skin development Scientific Data · 2022 · 2 citations
    8. Deciphering a Message from the Nucleus: How Transcription Factors and Spatial Chromatin Interactions Orchestrate Epidermal Differentiation 2023
    9. 766 H3K9me3 methyltransferase SETDB1 controls retrotransposon silencing, DNA methylation, constitutive heterochromatin maintenance and 3D-chromatin structure in epidermal keratinocytes 2023
    10. AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma Nature Communications · 2020 · 60 citations
    11. Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of <i>Foxn1</i> in Thymic Epithelial Cells 2019 · 17 citations
    12. A multi-omic single-cell landscape of perinatal mouse skin maps lineage specification and reveals shared dynamics in human fetal skin Experimental & Molecular Medicine · 2026
    13. 1438 KLF4 maintains hair follicle stem cell quiescence 2023
    14. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell stem cell · 2016 · 174 citations
    15. Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease bioRxiv (Cold Spring Harbor Laboratory) · 2022
    16. Is There a Histone Code for Cellular Quiescence? Frontiers in Cell and Developmental Biology · 2021 · 27 citations
    17. MultiKano: an automatic cell type annotation tool for single-cell multi-omics data based on Kolmogorov–Arnold network and data augmentation Protein & Cell · 2024 · 4 citations
    18. Surface-induced mechano-regulation of macrophages: emerging strategies for immunotherapy Med-X · 2026
    19. Identification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome Advanced Science · 2026
    20. ATP-dependent chromatin remodeling during mammalian development Development · 2016 · 182 citations
    21. Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata Frontiers in Immunology · 2025 · 4 citations
    22. Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression Cell stem cell · 2018 · 85 citations
    23. Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo eLife · 2023 · 23 citations
    24. The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates Nature cell biology · 2023 · 6 citations
    25. Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging Frontiers in Aging · 2023 · 3 citations
    26. p63 regulates <i>Satb1</i> to control tissue-specific chromatin remodeling during development of the epidermis The Journal of Cell Biology · 2011 · 166 citations
    27. The Paradox of p53: What, How, and Why? Cold Spring Harbor Perspectives in Medicine · 2016 · 64 citations
    28. Nuclear Topology, Epigenetics, and Keratinocyte Differentiation Journal of Investigative Dermatology · 2013 · 2 citations
    29. Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease Stem cell biology and regenerative medicine · 2018
    30. Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases Nature Genetics · 2023 · 47 citations