TLDR Key skin cell regulators and gene organization changes are crucial for skin cell development and could help treat skin disorders.
The study by Nayak et al., 2023, investigated the process of keratinocyte differentiation in the mouse epidermis, focusing on the role of transcription factors and chromatin organization. They found that during terminal differentiation, there is a significant downregulation of genes (82%) with an increase in transcriptional activity of genes related to epidermal barrier formation. Techniques such as ATAC-seq and Hi-C-seq revealed increased chromatin accessibility and looping at differentiation-associated genes, while ChIP-seq showed active enhancers related to epithelial differentiation. Transcription factors Dlx3, Klf4, and Grhl3 were identified as key regulators, with Dlx3 being essential for chromatin accessibility and gene transcription. This research enhances the understanding of keratinocyte differentiation and could inform treatments for related disorders.
3 citations,
January 2023 in “Science advances” The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.
38 citations,
April 2017 in “PLOS Genetics” GRHL3 is important for controlling gene activity in skin cells during different stages of their development.
118 citations,
January 2016 in “Current Topics in Developmental Biology” The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.
321 citations,
March 2015 in “Nature” Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
3 citations,
January 2023 in “Science advances” The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.
22 citations,
April 2020 in “Scientific reports” Changthangi goats have specific genes that help produce Pashmina wool.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” AP-2α and AP-2β proteins are essential for healthy adult skin and hair.
66 citations,
March 2019 in “Cellular and Molecular Life Sciences” Melanocyte development from neural crest cells is complex and influenced by many factors, and better understanding could help treat skin disorders.
