January 2026 in “Revista Científica de la Facultad de Ciencias Veterinarias” This study concluded that both ozonated oil and Centella asiatica extract effectively accelerated wound healing in mice through different mechanisms, with the former enhancing early-stage inflammation and the latter promoting collagen deposition and regenerative healing.
December 2025 in “International Journal of Molecular Sciences” In this study, orally administered Centella asiatica extract, standardized for asiaticoside content, significantly improved skin barrier function, elasticity, and reduced signs of UVB-induced photoaging in hairless mice, highlighting its potential as a nutricosmetic for skin health.
13 citations
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October 2017 in “Bioscience, Biotechnology, and Biochemistry” This study found that a titrated extract of Centella asiatica enhanced the hair growth potential of 3D spheroid cultured human dermal papilla cells.
3 citations
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January 2018 in “Chiang Mai University Journal” This study found that while the EtOAc fraction of Centella asiatica had the highest antioxidant activity, it was toxic to human follicle dermal papilla cells, but the EtOH crude extract promoted hair growth by enhancing VEGF expression.
February 2025 in “Natural Product Communications” This study found that combining natural extracts significantly boosted the stem cell functions of dermal papilla cells by enhancing β-catenin stability, promoting hair growth potential in vitro.
December 2018 in “Esperienze dermatologiche” A lotion with Centella asiatica extract reduced hair loss by 41% and increased hair strength without side effects.
December 2021 in “Jurnal ilmiah Manuntung” This study tested a hair tonic containing gotu kola and garlic extracts on rabbits, finding that the formulation with 5% gotu kola and 0.04% garlic showed promising hair growth results and remained stable during storage.
October 2024 in “Current Trends in Biotechnology and Pharmacy” In this study, researchers developed a halal shampoo containing Centella asiatica and Phyllanthus emblica extracts, finding that a formula with specific concentrations exhibited high antioxidant activity and ideal physicochemical properties for hair cleansing and potential hair growth promotion.
January 2024 in “AIP conference proceedings” This review reports that medicinal plant-based hydrogel films may enhance diabetic wound healing by increasing growth factor expression involved in tissue repair and regeneration, suggesting their potential in future diabetic wound dressing development.
December 2021 in “Bandung Conference Series. Pharmacy” This literature review found that combinations of certain herbal extracts with coconut oil, such as Hibiscus rosa sinensis and Centella asiatica, promoted hair growth in animals over 30 days, with varied results across rat and rabbit models.
January 2020 in “대한미용학회지” This review discusses various natural substances used in scalp improvement cosmetics and reports their potential benefits, without providing new clinical results, and suggests more comprehensive studies are needed.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study aimed to create and assess a trio pack of polyherbal hair care products, noting potential advantages such as reduced side effects and chemical use, though results are not reported in the abstract.
8 citations
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January 2011 This study observed that a polyherbal ointment containing extracts from several plants promoted significant hair growth in rats compared to using single plant extracts.
January 2019 in “International Journal of Herbal Medicine” This study concluded that a hair emulgel formulation combining extracts from four medicinal plants demonstrated desirable characteristics of spreadability, viscosity, pH, and safety, making it effective, harmless, and economical for potential hair care use.
August 2021 in “Prosiding Farmasi” This literature review found that combining coconut oil with various herbal extracts can promote hair growth in rats and rabbits, with different combinations producing varying hair length increases over 18 to 30 days.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study aims to formulate and evaluate a new trio pack consisting of shampoo, conditioner, and serum with botanical extracts, targeting hair and scalp maintenance and growth, as such a comprehensive formulation is currently not available in the market.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study aims to create and evaluate a novel trio pack of polyherbal hair care products, that includes a shampoo, conditioner, and serum, leveraging diverse botanical extracts known for promoting hair growth and scalp health, while reducing side effects typical of chemical-based cosmetics.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study aims to develop and evaluate a trio pack of polyherbal hair care products—including shampoo, conditioner, and serum—with the goal of promoting hair and scalp health due to the benefits of herbal ingredients and minimal side effects.
17 citations
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February 2015 in “Phytochemistry Reviews” This review discusses the cosmetic potential of Southeast Asian herbs and highlights the need for more systematic scientific evaluation of their efficacy and safety.
November 2025 in “Cosmetics” In this exploratory randomized controlled trial, participants using a combination of Centella asiatica-derived extracellular vesicles with recombinant growth factors showed significant improvements in hair thickness, density, length, and reduced hair loss and scalp sebum content after 56 days, compared to placebo.
2 citations
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July 2020 in “Journal of Applied Pharmaceutical Science” This study examined the preservative and antimicrobial susceptibility of non-fermenting bacilli collected from beauty salon waste in Brazil.
170 citations
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September 2019 in “Evidence-based Complementary and Alternative Medicine” This review discusses the use of 36 medicinal plant species for cutaneous wound healing and reports no new clinical results; the authors highlight the potential for these traditional practices to inform modern therapies.
January 2026 in “Frontiers in Bioscience-Landmark” This study reported that, in a laboratory setting, araliadiol derived from Centella asiatica activated antioxidant pathways, mitigating urban particulate matter-induced oxidative stress and skin damage.
July 2023 in “International journal of pharmacognosy and life science” This study explores the development of a herbal hair oil formulation using selected herbs to potentially address hair loss and related issues, as an alternative to synthetic medications that may cause serious side effects and offer limited effectiveness.
March 2026 in “Pharmaceutical Biology” This review discusses the potential of asiaticoside from Centella asiatica for enhancing wound healing after endoscopic submucosal dissection and highlights delivery strategies to improve its gastrointestinal application; it reports no new clinical results.
December 2024 in “Frontiers in Pharmacology” In this study, human cell models of hair follicles showed that araliadiol, a plant-derived polyacetylene compound, promotes hair growth through the p38/PPAR-γ signaling pathway, suggesting its potential as a new drug candidate for alopecia treatment.
August 2024 in “Faedah Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia” In this community outreach, participants in Langkat were educated about the benefits of gotu kola leaves as a natural facial moisturizer, resulting in improved knowledge, especially among children, teenagers, and mothers, as shown by pre- and post-test gains.
5 citations
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July 2022 in “International Journal of Health Sciences” In this study, researchers formulated a hair tonic using various herbal extracts and reported effective antifungal and antibacterial properties, along with good consistency, spreadability, homogeneity, appearance, and pH balance.
92 citations
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December 2020 in “Brain Sciences” This review discusses the potential of various Indian herbal medicines in treating cognitive impairment related to Alzheimer's disease but reports no new clinical findings; it highlights the need for further research.
January 2026 in “Frontiers in Natural Products” This study found that combining shikimic acid with Prunus mume fruit extract significantly reduces type I 5α-reductase levels in testosterone-stressed skin sebocytes, surpassing the effects of shikimic acid or standard acne treatments alone, and shows promise for stable, non-irritating acne remedies in cosmetic formulations.