Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In laboratory tests, this study found that a novel natural composition targeting 5-alpha reductase and inflammatory pathways reduced disease-related markers in androgenetic alopecia and benign prostatic hyperplasia more effectively than finasteride.

This study reported that ELL is crucial for maintaining the proliferative capacity of the basal layer in human epidermal keratinocytes by stabilizing RNA polymerase II at the transcription start site.

This study found that the culture conditions, not species-specific differences, determined whether sika deer dermal papilla cells adopted a 3D spheroidal or 2D monolayer growth pattern, influencing their hair-inducing ability.

This study introduces a modular fiber model to investigate how changes in microstructural properties of wool affect its critical buckling load, highlighting potential uses and areas needing further research in wool fiber biophysics.

This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.

In this study, researchers identified that upon tissue injury in a mouse model, epidermal cells at the wound edge convert to an embryonic-like state with SOX11 and SOX4 playing a central role in modulating epidermal development and cell migration genes.

This study found that the transcription factor FOXO1 plays a crucial role in wound healing by protecting keratinocytes from oxidative stress and regulating TGF-β expression.

This review discusses current knowledge on the biological mechanisms of different types of alopecia but reports no new clinical findings; the authors highlight future research directions, especially regarding epidermal stem cells and immune pathways.

This study found significant differences in gene expression between newborn and adult skin, with infant skin notably increasing processes related to ECM organization, cell adhesion, and collagen fibril organization.

This study found that specific gene upregulations and mutations in hidradenitis suppurativa skin support the role of inflammation, altered epithelial differentiation, and metabolism dysregulation in the disease's pathogenesis.

This review discusses sex differences in immune response to respiratory viral infections, including SARS-CoV-2, and highlights that hormones like estrogen may provide females with better protection, but it reports no new results.

This review outlines the current understanding of how pH contributes to root hair development and reports no new experimental findings.

This case report describes a rare instance of a Leydig cell tumor in a 35-year-old pregnant woman, discovered incidentally during a cesarean section. The tumor typically presents with symptoms of excess androgen, though it can range from asymptomatic to rapid virilization.

In this review, it is discussed how mesenchymal stem cell aggregation plays a crucial role in organ development and has potential applications in organ regeneration through tissue engineering.

The Celsr1 gene is crucial for normal hair patterning in mice.

This study found that BRG1 is crucial for keratinocyte migration during skin wound healing, as its suppression impairs wound closure by inhibiting migration without affecting cell proliferation or apoptosis.

This review examines the interaction between the extracellular matrix and immune cells in skin diseases and evaluates advanced therapies that target involved molecular mechanisms, reporting no new clinical findings.

This study used single-cell RNA sequencing to characterize 19 distinct cell populations in sheep hair follicles, uncovering differentiation signatures and intercellular communication that may influence wool curvature and sheep breeding.

This case report from a German study detailed a 2-year-old girl with virilization and precocious puberty due to a rare ovarian steroid cell tumor, finding that post-surgery, her elevated hormone levels normalized within a week, and ongoing follow-up showed no need for chemotherapy.

This review highlights various methods of stem cell communication that reflect the unique organization and function of different tissues and reports no new results.

This study used developing mouse hair follicles to explore early epithelial bud formation, finding that the Rho GTPase regulator ARHGEF3 plays a crucial role in regulating cell fate and cadherin patterning, with knockouts showing disrupted morphology and increased straight hair follicle growth.

This study found that pediatric alopecia areata patients with atopic predisposition showed heightened immune and inflammatory responses, including significant immune cell infiltration, compared to adults and healthy controls.

This study established a new in vitro culture system that supports the growth and dynamic self-organization of hair follicle stem cells and their progeny, promoting a stable population equilibrium.

This study found that stem cells derived from spinal and bulbar muscular atrophy patients exhibited reduced androgen receptor levels and HDAC6, providing potential insights into the disease mechanism for future therapies.

This case report describes a 60-year-old woman with an ovarian Leydig cell tumor leading to elevated testosterone levels and hirsutism, highlighting the need to consider androgen-secreting tumors in similar postmenopausal cases.

This case study describes a 15-year-old girl with a Sertoli–Leydig cell tumor who showed high androgen levels and steroidogenic responses similar to patients with polycystic ovary syndrome before surgery.

This paper reviews the role of ATP-dependent chromatin remodeling complexes in epidermal homeostasis, hair regeneration, and skin repair, noting contributions to 3D-genomic organization and suppression of UV-induced hyper-proliferation, without presenting new results.

This study introduces stem cell activity as a key factor influencing the effects of IFN-γ and TGF-β1 on autoimmune disease dynamics, showing that varying cytokine levels can modulate stem cell activity and immune privilege, impacting tissue regeneration and disease flares.

This study found that in adult mouse skin, reduced levels of histone H3 K4/K9/K27me3 during hair follicle stem cell quiescence are linked to proper tissue homeostasis.

This study found that mesenchymal stem cells derived from dental pulp and adipose tissue have distinct gene expression signatures that suggest potential target diseases for clinical applications.