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GlossaryCell Proliferation Marker

substance indicating cell division and growth rates

A Cell Proliferation Marker is a substance or molecule used to detect and measure the rate at which cells are dividing and growing. These markers are crucial in both research and clinical settings to understand cell growth patterns, especially in contexts like cancer research, tissue regeneration, and hair growth studies. Common examples include Ki-67 and BrdU, which are often used to identify actively dividing cells.

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research Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis

52 citations, February 2012 in “PloS one”

Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.

Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

research Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

13 citations, September 2020 in “International Journal of Molecular Sciences”

PRP therapy and minoxidil combo works best for male hair loss.

research Y27632 Promotes Proliferation via EGFR Signaling in a Newly Isolated and Characterized Human Primary Sebocyte Cell Line

April 2019 in “Journal of Investigative Dermatology”

Y27632 increases cell growth through EGFR signaling, not ROCK1/2.

research ELL Facilitates RNA Polymerase II-Mediated Transcription of Human Epidermal Proliferation Genes

4 citations, May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

ELL is crucial for gene transcription related to skin cell growth.

research SP1 and KROX20 Regulate the Proliferation of Dermal Papilla Cells and Target the CUX1 Gene

January 2024 in “Animals”

SP1 promotes and KROX20 inhibits hair cell growth by affecting the CUX1 gene.

research CRABP1 Enhances Proliferation of Dermal Papilla Cells in Hu Sheep via Wnt/β-Catenin Pathway

September 2024 in “Genes”

CRABP1 boosts hair cell growth in Hu sheep by affecting key genes.

research Costunolide Promotes the Proliferation of Human Hair Follicle Dermal Papilla Cells and Induces Hair Growth in C57BL/6 Mice

21 citations, May 2018 in “Journal of Cosmetic Dermatology”

Costunolide helps human hair cells grow and can stimulate hair growth in mice.

research Effects of Periplaneta Americana Extracts on the Growth and Proliferation of Cutaneous Interstitial Cells in Cutaneous-Wound Healing

9 citations, August 2022 in “Frontiers in Pharmacology”

Kangfuxin (KFX) extract speeds up wound healing and improves skin regeneration.

Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in C57BL/6 Mice Through Upregulation of the RAS/ERK Signaling Pathway

research Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in C57BL/6 Mice Through Upregulation of the RAS/ERK Signaling Pathway

November 2024 in “Journal of Translational Internal Medicine”

Exosomes from stem cells help hair regrowth by activating a specific signaling pathway.

research Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers

33 citations, August 2013 in “Journal of Investigative Dermatology”

Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.

Intrinsic Activation of Cell Growth and Differentiation in Ex Vivo Cultured Human Hair Follicles by a Transient Endogenous Production of ROS

research Intrinsic Activation of Cell Growth and Differentiation in Ex Vivo Cultured Human Hair Follicles by a Transient Endogenous Production of ROS

9 citations, March 2019 in “Scientific reports”

Temporary ROS production in cultured human hair follicles promotes growth and stem cell activation.

Traditional Chinese Medicine Shi-Bi-Man Regulates Lactic Acid Metabolism and Drives Hair Follicle Stem Cell Activation to Promote Hair Regeneration

research Traditional Chinese Medicine Shi-Bi-Man Regulates Lactic Acid Metabolism and Drives Hair Follicle Stem Cell Activation to Promote Hair Regeneration

1 citations, July 2023 in “Chinese Medicine”

Shi-Bi-Man, a Traditional Chinese Medicine, helps grow hair by boosting lactic acid metabolism and activating hair follicle stem cells.

research Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

13 citations, September 2021 in “Current Issues in Molecular Biology”

Dexpanthenol helps human hair follicle cells grow by preventing aging and death, and by supporting growth signals.

research Transforming Growth Factor-Alpha Immunoreactivity During Induced Hair Follicle Growth Cycles in Sheep and Ferrets

6 citations, April 1996 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

TGF-alpha is present in sheep and ferret skin and may affect hair growth without directly stimulating cell proliferation.

research Blackcurrant Extract with Phytoestrogen Activity Alleviates Hair Loss in Ovariectomized Rats

9 citations, April 2019 in “Molecules”

Blackcurrant extract may help reduce hair loss by promoting stem cell activity in hair follicles.

research Enrichment and Characterization of Human Dermal Stem/Progenitor Cells by Intracellular Granularity

10 citations, January 2013 in “Stem Cells and Development”

Scientists identified a unique type of human skin stem cell that could help with tissue repair.

research The Effect of EGR1 on the Proliferation of Dermal Papilla Cells

5 citations, July 2022 in “Genes”

Increasing EGR1 levels makes hair root cells grow faster.

research Macrophage-Derived Extracellular Vesicle Promotes Hair Growth

51 citations, April 2020 in “Cells”

Special cell particles from macrophages can help hair grow.

research Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway

25 citations, September 2020 in “Molecules”

Quercitrin may help treat hair loss by promoting hair growth and improving cell health.

Pharmacological Activation of Estrogen Receptors-α and -β Differentially Modulates Keratinocyte Differentiation with Functional Impact on Wound Healing

research Pharmacological Activation of Estrogen Receptors-α and -β Differentially Modulates Keratinocyte Differentiation with Functional Impact on Wound Healing

23 citations, September 2015 in “International Journal of Molecular Medicine”

Activating ER-β, not ER-α, improves skin cell growth and wound healing.

Combination of an Engineered Lactococcus Lactis Expressing CXCL12 with Light-Emitting Diode Yellow Light as a Treatment for Scalded Skin in Mice

research Combination of an Engineered Lactococcus Lactis Expressing CXCL12 with Light-Emitting Diode Yellow Light as a Treatment for Scalded Skin in Mice

6 citations, July 2021 in “Microbial biotechnology”

The combined treatment with engineered bacteria and yellow LED light improved wound healing in mice.

research Thyroid Hormone Receptor Agonist Promotes Hair Growth in Mice

1 citations, February 2022 in “Clinical, Cosmetic and Investigational Dermatology”

TDM10842, a thyroid hormone receptor activator, was found to effectively promote hair growth in mice.

research Ganoderma Lucidum Extract Attenuates Corticotropin-Releasing Hormone Induced Cellular Senescence in Human Hair Follicle Cells

April 2024 in “iScience”

Ganoderma lucidum extract may help treat stress-related hair loss.

research The In Vivo and In Vitro Effects of Terminalia Bellirica Fruit Extract on Testosterone-Induced Hair Loss

July 2023 in “Journal of Microbiology and Biotechnology”

Terminalia bellirica extract may help promote hair growth and prevent hair loss caused by testosterone.

research Faculty Opinions Recommendation of The Effect of Autologous Activated Platelet-Rich Plasma (AA-PRP) Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

July 2014 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

AA-PRP injections significantly promote hair growth but need better study design for clear efficacy.

research CD133-Positive Dermal Papilla-Derived Wnt Ligands Regulate Postnatal Hair Growth

15 citations, July 2016 in “Biochemical Journal”

Wnt proteins from certain skin cells are crucial for normal hair growth and renewal.

research Sustained Human Hair Follicle Growth Ex Vivo in a Glycosaminoglycan Hydrogel Matrix

9 citations, April 2019 in “International journal of molecular sciences”

Human hair grows better in a special gel that mimics skin.

research Hair Growth Promoting Effect of Urtica Dioica L

September 2018 in “Central Asian journal of medical sciences (Print)”

Urticadioica L extract may enhance human hair growth.

research Impact of Cernitin on Induced Chronic Prostatitis in Animal Model for Understanding Management of Lower Urinary Tract Symptoms

1 citations, March 2021 in “Phytomedicine plus”

Cernitin™, a pollen extract, was found to significantly reduce pain and inflammation in rats with chronic prostatitis, suggesting it could be a useful alternative to certain anti-inflammatory drugs.

research Nanostructured Lipid Carriers Loaded with Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia

9 citations, February 2022 in “European Journal of Pharmaceutics and Biopharmaceutics”

A new treatment for hair loss uses tiny lipid carriers to deliver a mix of minoxidil and latanoprost directly to hair follicles, promoting hair growth and being well tolerated by the skin.